磷酸肌酸钠联合维生素C治疗小儿病毒性心肌炎的效果OA

Objective:To observe the efficacy of creatine phosphate sodium combined with vitamin C in the treatment of children with viral myocarditis.Methods:A total of 106 children with viral myocarditis admitted to a hospital from May 2020 to December 2023 were selected and divided into control group and observation group by envelope method,with 53 patients in each group.The control group was given conventional treatment such as ribavirin injection,ubidecarenone,etc.,and the observation group was given creatine phosphate sodium combined with vitamin C in addition to the conventional treatment.The levels of cardiac enzymes,cardiac function indicators,monocyte chemoattractant protein-1(MCP-1)and high mobility group protein B1(HMGB1)were compared between the two groups before and after treatment,and the clinical efficacy and safety were also compared between the two groups.Results:After treatment,the levels of lactate dehydrogenase(LDH),creatine kinase MB isoenzyme(CK-MB),hydroxybutyric dehydrogenase(HBDH),creatine kinase(CK),cardiac troponin I(cTnI),MCP-1,HMGB1,pentraxin-3(PTX-3),intercellular adhesion molecule-1(ICAM-1),high-sensitivity C-reactive protein(hs-CRP),interleukin-18(IL-18)were all decreased in both groups,and were lower in the observation group than those in the control group(P<0.05);the left ventricular ejection fraction(LVEF),cardiac index(CI)and fractional shortening(FS)were increased(P<0.05);the total effective rate in the observation group(90.57%)was higher than that in the control group(75.00%,P<0.05);there was no statistically significant difference in the total incidence of adverse reactions between the two groups.Conclusion:Creatine phosphate sodium combined with vitamin C for viral myocarditis in children exhibited improved levels of measures such as cardiac enzymes,MCP-1,and HMGB1,and better clinical efficacy,without additional adverse reactions.