脑脊液单细胞测序技术在神经退行性疾病中的应用进展OA北大核心CSTPCD

With the development of single-cell sequencing technology for cerebrospinal fluid(CSF),its application in the study of neurodegenerative diseases is increasingly widespread.This article summarizes relevant literature in recent years and outlines the application of CSF single-cell sequencing technology in neurodegenerative diseases,including using this technology to discover disease-specific cells and differentially expressed genes in neurodegenerative diseases,improving the accuracy of disease diagnosis by combining with cytological markers,and designing targeted therapies by identifying key signaling pathways and antigen targets.In summary,multi-omics detection helps understand cell states from a multi-dimensional perspective.CSF single-cell sequencing technology has a promising application in neurodegenerative disease research.