中国医学前沿杂志（电子版）2024，Vol.16Issue(6)：52-57,6.DOI:10.12037/YXQY.2024.06-09
脑脊液单细胞测序技术在神经退行性疾病中的应用进展
Progress in cerebrospinal fluid single-cell sequencing in neurodegenerative diseases
摘要
Abstract
With the development of single-cell sequencing technology for cerebrospinal fluid(CSF),its application in the study of neurodegenerative diseases is increasingly widespread.This article summarizes relevant literature in recent years and outlines the application of CSF single-cell sequencing technology in neurodegenerative diseases,including using this technology to discover disease-specific cells and differentially expressed genes in neurodegenerative diseases,improving the accuracy of disease diagnosis by combining with cytological markers,and designing targeted therapies by identifying key signaling pathways and antigen targets.In summary,multi-omics detection helps understand cell states from a multi-dimensional perspective.CSF single-cell sequencing technology has a promising application in neurodegenerative disease research.关键词
脑脊液/单细胞测序技术/神经退行性疾病Key words
Cerebrospinal fluid/Single-cell gene expression Analysis/Neurodegenerative diseases引用本文复制引用
赵卫然,刘小璇,何及..脑脊液单细胞测序技术在神经退行性疾病中的应用进展[J].中国医学前沿杂志（电子版）,2024,16(6):52-57,6.基金项目
National Natural Science Foundation General Project(81974197) （81974197）
Beijing Natural Science Foundation General Project(7222215) （7222215）
Peking University Third Hospital Queue Study(BYSYDL2021007) （BYSYDL2021007）
Clinical Key Project of Peking University Third Hospital(BYSYZD2022009) （BYSYZD2022009）
Beijing Physician Scientist Training Project(BJPSTP-2024-03) 国家自然科学基金面上项目(81974197) （BJPSTP-2024-03）
北京市自然科学基金面上项目(7222215) （7222215）
北京大学第三医院队列研究(BYSYDL2021007) （BYSYDL2021007）
北京大学第三医院临床重点项目(BYSYZD2022009) （BYSYZD2022009）
北京市医师科学家培养计划资助(BJP-STP-2024-03) （BJP-STP-2024-03）
