摘要
Abstract
Objective:To explore the therapeutic effect of Magnesium Isoglycyrrhizinate(MI)combined with Ademetionine 1,4-Butanedisulfonate(SAM)in patients with liver function damage after transcatheter hepatic artery chemoembolization(TACE).Method:A total of 94 patients with liver injury after TACE surgery admitted to Yankuang New Journey General Hospital from April 2021 to April 2023 were selected and divided into two groups by random number table method,with 47 cases in each group.The control group was treated with MI,while the observation group was treated with SAM for two weeks.The clinical efficacy,liver function indicators,serological indicators,quality of life,and incidence of adverse reactions between two groups were compared.Result:The total effective rate of the observation group was 93.62%,which was higher than 78.72%in the control group(P<0.05).Before treatment,there were no statistically significant differences in liver function indicators,serological indicators,and quality of life between the two groups(P>0.05);after treatment,aspartate aminotransferase(AST)was(51.63±5.24)U/L,alanine aminotransferase(ALT)was(60.28±7.01)U/L,glutamyl transpeptidase(GGT)was(61.32±7.93)U/L,and total bilirubin(TBIL)was(23.54±3.56)μmol/L,tumor necrosis factor-α(TNF-α)was(3.26±0.38)ng/L,interleukin-6(IL-6)was(31.14±7.55)pg/mL,and hypersensitive C reactive protein(hs-CRP)was(2.55±0.45)mg/L in the observation group,which were lower than(62.73±6.39)U/L,(72.90±9.28)U/L,(72.46±9.54)U/L,and(29.48±5.41)μmol/L,(3.82±0.59)ng/L,(46.69±6.04)ng/L,(3.57±0.58)mg/L in the control group;the physiological domain score(76.46±5.24)points,psychological domain score(75.17±4.73)points,social domain score(74.53±6.61)points,and environmental domain score(76.25±5.25)points in the GQOLI-74 questionnaire,which were higher than(70.37±5.12),(69.15±5.35),(66.71±5.80),and(70.03±4.59)points in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of MI and SAM can improve liver function in patients with liver injury after TACE,promote the normalization of serum indicators,improve the quality of life of patients,and is safe and reliable.关键词
经导管肝动脉化疗栓塞/异甘草酸镁/丁二磺酸腺苷蛋氨酸/肝损伤/不良反应Key words
Transcatheter hepatic artery chemoembolization/Magnesium Isoglycyrrhizinate/Ademetionine1,4-Butanedisulfonate/Liver injury/Adverse reactions
