中国实用外科杂志2024，Vol.44Issue(6)：680-684,5.DOI:10.19538/j.cjps.issn1005-2208.2024.06.15
分化型甲状腺癌骨转移危险因素及预后指标研究
Study on risk factors and prognostic indicators of bone metastasis in thyroid cancer
摘要
Abstract
Objective To investigate the risk factors and prognostic indicators of bone metastasis in differentiated thyroid cancer(DTC).Methods A retrospective analysis was conducted on 43 DTC patients with bone metastasis admitted to the First Affiliated Hospital of Zhengzhou University from January 2018 to September 2023 as the metastasis group.Data from 1457 DTC patients without bone metastasis treated during the same period were randomly selected as the non-bone metastasis group.Nine factors including general information,postoperative pathological types,and maximum tumor diameter were collected and analyzed.SPSS 27.0 software was used for statistical analysis,and x2 test and Logistics regression analysis were applied to investigate the correlation between various risk factors and bone metastasis.In addition,a retrospective analysis was performed on 82 DTC patients with postoperative bone metastasis admitted to the First Affiliated Hospital of Zhengzhou University from January 2012 to September 2023.General information,pathological type,first symptoms,treatment methods,and other factors were collected.The Log-rank test was applied to analyze whether there were statistically significant differences between groups.Multivariate COX proportional hazards regression analysis was used to identify factors influencing disease progression.Results In the bone metastasis group,patients aged ≥55 years,with pathological type of follicular carcinoma,cervical lymph node metastasis,combined with other distant metastases,and the presence of extrathyroidal extension of tumor were significantly higher than those in the non-bone metastasis group(P＜0.05).The lack of cervical lymph node dissection(P=0.07)was marginally correlated and was a risk factor for bone metastasis in DTC patients.In the predictive analysis,COX proportional hazards regression analysis revealed that pathological type,presence of other distant metastases,first symptoms,iodine uptake by metastatic lesions,and different treatment methods were statistically significant(P＜0.05).Conclusion Age,follicular carcinoma,lack of cervical lymph node dissection,cervical lymph node metastasis,combined with other distant metastases,and the presence of extrathyroidal extension of tumor are risk factors for bone metastasis in DTC patients.Pathological type,presence of other distant metastases,first symptoms,iodine uptake by metastatic lesions,and different treatment modalities are important factors affecting the prognosis of DTC patients.关键词
分化甲状腺癌/骨转移/危险因素/预后Key words
differentiated thyroid cancer/bone metastasis/risk factors/prognosis分类
医药卫生引用本文复制引用
冯贵铖,李红强,柳桢,唐艺峰,刘益豪,郭跃,殷德涛..分化型甲状腺癌骨转移危险因素及预后指标研究[J].中国实用外科杂志,2024,44(6):680-684,5.基金项目
河南省自然科学基金面上项目(No.222300420568) （No.222300420568）
河南省医学科技攻关重大计划项目(No.SBGJ202101014) （No.SBGJ202101014）
河南省中医药研究重大专项(No.20-21ZYZD14) （No.20-21ZYZD14）
河南省中青年医学科技创新领军人才项目(No.YXKC2020015) （No.YXKC2020015）
