摘要
Abstract
Objective:To investigate the effect of different doses of Propylthiouracil in the treatment of pregnancy complicated with hyperthyroidism.Method:A total of 70 pregnant patients with hyperthyroidism admitted to Department of Obstetrics and Gynecology,People's Hospital of Ruijin City from September 2021 to March 2023 were randomly divided into low-dose group(was initially given Propylthiouracil 50 mg/time,3 times/day)and high-dose group(was initially given Propylthiouracil 100 mg/time,3 times/day),both groups were treated for 2 months.The therapeutic effect and drug safety of the two groups were evaluated,the coagulation function,liver function and thyroid function of the two groups before and after treatment were compared,and adverse pregnancy outcomes were counted.Result:After treatment,the prohemase time(PT)and thrombin time(TT)in the high-dose group were longer than those in the low-dose group,and the fibrinogen(FIB)and D-dimer(D-D)in the high-dose group were lower than those in the low-dose group(P<0.05).After treatment,the levels of γ-glutamyltransferase(GGT),total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST)and alkaline phosphatase(ALP)in the two groups were higher than those before treatment,and the levels of the above indexes in low-dose group were lower than those in high-dose group(P<0.05).Compared with before treatment,the levels of free thyroxine(FT4),free triiodothyronine(FT3)and total thyroid hormone(TT4)in both groups after treatment were decreased,those in the high-dose group were lower than those in the low-dose group,the thyroid stimulating hormone(TSH)in both groups were increased,and that in the high-dose group were higher that in the low-dose group(P<0.05).There were no significant difference in the total effective rate,pregnancy outcome and incidence of adverse reactions between the two groups(P>0.05).Conclusion:The clinical effect of different doses of Propylthiouracil in the treatment of pregnancy complicated with hyperthyroidism is similar.High-dose Propylthiouracil can improve the hypercoagulability of patients,while low-doses Propylthiouracil can effectively reduce the damage of liver function.关键词
妊娠/甲状腺功能亢进症/丙硫氧嘧啶/凝血系统/肝功能Key words
Pregnancy/Hyperthyroidism/Propylthiouracil/Coagulation system/Liver function
