中国医学创新2024，Vol.21Issue(18)：23-27,5.DOI:10.3969/j.issn.1674-4985.2024.18.006
比伐芦定联合冠脉内注射替罗非班预防ST段抬高型心肌梗死患者PCI术中无复流的效果
Effect of Bivalirudin Combined with Intra-Coronary Injection of Tirofiban on Preventing No-reflow during PCI in Patients with ST Segment Elevation Myocardial Infarction
摘要
Abstract
Objective:To observe the effect of Bivalirudin combined with intra-coronary injection of Tirofiban on preventing of no-reflow during percutaneous coronary intervention(PCI)in patients with ST segment elevation myocardial infarction(STEMI).Method:A total of 95 patients with STEMI admitted to Yichun Second People's Hospital from January 2018 to June 2022 were selected and randomly divided into control group(n=40)and observation group(n=45).The control group was treated with preventive intra-coronary injection of Tirofiban,while the observation group was treated with Bivalirudin combined with intra-coronary injection of Tirofiban.The incidence of intraoperative reflow,thrombolysis in myocardial infarction(TIMI)frame number,TIMI blood flow grade,occurrence of cardiovascular adverse events,and complications of the two groups were statistically analyzed.Result:The incidence of no-reflow and TIMI frame number after PCI in observation group were lower than those in control group,and TIMI blood flow grade after PCI was better than that in control group,the differences were statistically significant(P<0.05).The total incidence of cardiovascular adverse events in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of bleeding complications between the two groups(P>0.05).Conclusion:Compared with preventive intra-coronary injection of Tirofiban,Bivalirudin combined with intra-coronary injection of Tirofiban is more effective in preventing and treating no-reflow during PCI in STEMI patients,which is helpful for formulating individualized treatment plan for preventing no-reflow,so as to obtain better immediate target blood flow and good curative effect in later period.关键词
ST段抬高型心肌梗死/经皮冠状动脉介入治疗/无复流/比伐芦定/冠脉内注射替罗非班/心血管不良事件/出血并发症Key words
ST segment elevation myocardial infarction/Percutaneous coronary intervention/No-reflow/Bivalirudin/Intra-coronary injection of Tirofiban/Cardiovascular adverse events/Bleeding complications引用本文复制引用
房勇,阳成俊,刘青平,谭启林,邹小秋,巫玉婷..比伐芦定联合冠脉内注射替罗非班预防ST段抬高型心肌梗死患者PCI术中无复流的效果[J].中国医学创新,2024,21(18):23-27,5.基金项目
江西省卫生健康委普通科技计划项目(202212624) （202212624）
