摘要
Abstract
Objective:To explore the changes of blood procalcitonin(PCT),serum amyloid A(SAA)and interleukin-6(IL-6)levels in pregnant women with premature rupture of membranes and their relationship with chorioamnionitis.Method:The clinical data of 82 pregnant women with premature rupture of membranes admitted to Shangrao Municipal Hospital from August 2021 to August 2023 were retrospectively analyzed,and the results of microscopic examination of pathology section of fetal membranes after delivery were taken as the gold standard,and the pregnant women with chorioamnionitis were classified into the disease group(n=36),the pregnant women without chorioamnionitis were classified into the normal group(n=46).In addition,40 healthy pregnant women who underwent routine prenatal screening in author's hospital during the same period were selected as the health group.The difference of PCT,SAA and IL-6 levels in were compared between premature rupture of membranes group and health group,disease group and normal group.The receiver operator characteristic(ROC)curve was used to evaluate the predictive efficacy of the above three indexes alone and in combination for chorioamnionitis in pregnant women with premature rupture of membranes.Result:The levels of PCT,SAA and IL-6 in the premature rupture of membranes group were higher than those in the healthy group,and the levels of PCT,SAA and IL-6 in the disease group were higher than those in the normal group,the differences were statistically significant(P<0.05).The sensitivity,specificity and cut-off value of PCT prediction alone were 71.74%,83.33%and 2.19 μg/L respectively.The sensitivity,specificity and cutoff value of SAA prediction alone were 67.39%,94.44%and 10.75 mg/L respectively.The sensitivity,specificity and cut-off value of IL-6 prediction alone were 69.57%,80.56%and 76.40 ng/L respectively.The area under the curve(AUC),sensitivity and specificity of combined prediction of three indexes were 0.946,86.96%and 80.56%respectively.Conclusion:The levels of PCT,SAA and IL-6 in pregnant women with premature rupture of membranes have significant changes,and the combined prediction of the above indexes has a high efficiency.关键词
胎膜早破/孕妇/降钙素原/淀粉样蛋白A/白细胞介素-6/绒毛膜羊膜炎Key words
Premature rupture of membranes/Pregnant women/Procalcitonin/Serum amyloid A/Interleukin-6/Chorioamnionitis
