中国医学创新2024，Vol.21Issue(17)：1-5,5.DOI:10.3969/j.issn.1674-4985.2024.17.001
双管软通道引流术与显微镜下小骨窗开颅术治疗大血肿量高血压脑出血的效果及对炎症指标、氧化应激的影响
Effect of Double Hose Channel Drainage and Small Bone Window Craniotomy under Microscope in the Treatment of Hypertensive Cerebral Hemorrhage with Large Hematoma Volume and Its Influence on Inflammatory Indexes and Oxidative Stress
摘要
Abstract
Objective:To investigate and analyze the effect of double hose channel drainage and small bone window craniotomy under microscope in the treatment of hypertensive cerebral hemorrhage(HICH)with large hematoma volume and its influence on inflammatory indexes and oxidative stress.Method:A total of 136 patients with HICH treated in the Third Affiliated Hospital of Gannan Medical College from January 2020 to December 2022 were selected and randomly divided into control group(n=68)and experimental group(n=68).The control group was treated with small bone window craniotomy under microscope,and the experimental group was treated with double hose channel drainage.The clinical efficacy,inflammatory indexes[hypersensitive C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],oxidative stress[lipid peroxide(LPO),glutathione peroxidase(GSH-Px)and malondialdehyde(MDA)]and incidence of postoperative complications were compared between the two groups.Result:There was no significant difference in clinical efficacy between the two groups(P>0.05).1 week after surgery,the levels of hs-CRP,TNF-α and IL-6 in the two groups were significantly lower than those before surgery,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).1 week after surgery,LPO and MDA in both groups were significantly decreased compared with those before surgery,LPO and MDA in experimental group were lower than those in control group,GSH-Px were significantly increased compared with those before surgery,GSH-Px in experimental group was higher than that in control group,the differences were statistically significant(P<0.05).The incidence of postoperative complications in experimental group was significantly lower than that in control group,the difference was statistically significant(P<0.05).Conclusion:Both double hose channel drainage and small bone window craniotomy under microscope have good effects in the treatment of HICH,but double hose channel drainage can reduce the incidence of postoperative complications,and the postoperative inflammatory reaction and stress reaction are lighter.关键词
高血压脑出血/双管软通道引流术/显微镜下小骨窗开颅术/炎症指标/氧化应激Key words
Hypertensive cerebral hemorrhage/Double hose channel drainage/Small bone window craniotomy under microscope/Inflammatory indexes/Oxidative stress引用本文复制引用
康天保,谢玉娟,谢建辉..双管软通道引流术与显微镜下小骨窗开颅术治疗大血肿量高血压脑出血的效果及对炎症指标、氧化应激的影响[J].中国医学创新,2024,21(17):1-5,5.基金项目
赣州市指导性科技计划项目(20222ZDX9180) （20222ZDX9180）
