中国医学创新2024，Vol.21Issue(18)：41-45,5.DOI:10.3969/j.issn.1674-4985.2024.18.010
布地格福吸入气雾剂对慢性阻塞性肺疾病患者炎症反应及肺通气功能的影响研究
Study on the Influence of Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol on Inflammatory Response and Pulmonary Ventilation Function of Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective:To investigate the influence of Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol on inflammatory response and pulmonary ventilation function of patients with chronic obstructive pulmonary disease.Method:A total of 120 patients with chronic obstructive pulmonary disease in Nanchang Third Hospital from June 2022 to June 2023 were divided into control group 60 cases and observation group 60 cases by the method of random number table.The control group was treated with Budesonide and Formoterol Fumarate Powder for Inhalation,the observation group was treated with Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol.Then the total effective rates of chronic obstructive pulmonary disease treatment,adverse reactions rates,inflammatory response items[serum and sputum interleukin-8(IL-8)and interleukin-17(IL-17)]and pulmonary ventilation function[residual volume(RV),residual volume/total lung capacity(RV/TLC)and forced expiratory volume in one second as a percentage of expected value(FEV1%pred)]before and after the treatment of two groups were compared.Result:The total effective rate of chronic obstructive pulmonary disease treatment of observation group was significantly higher than that of control group,the total adverse reactions rate was significantly lower than that of control group,the differences were statistically significant(P<0.05),the inflammatory response items and pulmonary ventilation function of two groups before the treatment were compared,the differences were not statistically significant(P>0.05),the inflammatory response items and RV,RV/TLC of observation group at 6th and 12th week after the treatment were significantly lower than those of control group,the FEV1%pred were significantly higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol in the treatment of patients with chronic obstructive pulmonary disease is better,and it can significantly improve the inflammatory response and pulmonary ventilation function of patients,so its application value in patients with chronic obstructive pulmonary disease is higher.关键词
布地格福吸入气雾剂/慢性阻塞性肺疾病/炎症反应/肺通气功能Key words
Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol/Chronic obstructive pulmonary disease/Inflammatory response/Pulmonary ventilation function引用本文复制引用
董必文,习慧明,张艳霞..布地格福吸入气雾剂对慢性阻塞性肺疾病患者炎症反应及肺通气功能的影响研究[J].中国医学创新,2024,21(18):41-45,5.基金项目
江西省卫生健康委普通科技计划项目(202311295) （202311295）
