中国医学创新2024，Vol.21Issue(18)：45-49,5.DOI:10.3969/j.issn.1674-4985.2024.18.011
不同模式人工肝治疗对肝衰竭患者肝肾功能及凝血功能的影响
Effect of Different Modes of Artificial Liver Therapy on Liver and Kidney Function and Coagulation Function in Patients with Liver Failure
摘要
Abstract
Objective:To analyze the effects of artificial liver treatment in patients with liver failure.Method:A total of 75 patients with liver failure in Jiujiang NO.1 People's Hospital from January to September 2022 were selected,they were divided into group A,B,C by random number table method,each 25 cases.Group A underwent dual plasma molecular adsorption(DPMAS)+plasma exchange(PE),group B underwent plasma dialysis filtration(PDF),and group C underwent PE.Symptom improvement,laboratory indicators and the end-stage liver disease model(MELD)scores changes of the three groups were compared,and adverse reactions was calculated.Result:The effective rate and adverse reactions incidence rate of the three groups were basically consistent(P>0.05).There were no statistically significant differences in serum total bilirubin(TBIL),alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),albumin(ALB),international normalized ratio(INR),prothrombin activity(PTA),MELD score(P>0.05);after treatment,TBIL,ALT,AST,Cr,INR and MELD scores were decreased in all three groups compared with those before treatment,ALB and PTA were increased in group C compared with those before treatment,ALB and PTA were decreased in group A and group B compared with those before treatment(P<0.05);comparison of TBIL,ALT,AST,Cr,INR and MELD scores after treatment among three groups,the differences were not statistically significant(P>0.05);ALB and PTA were higher in group C than those in group A and group B(P<0.05).Conclusion:In patients with liver failure,the flexible application of DPMAS+PE,PDF and PE has good effect,with no obvious advantages or disadvantages,and has ideal application value for the improvement of clinical symptoms.关键词
人工肝/肝衰竭/血浆透析滤过/血浆灌流Key words
Artificial liver/Liver failure/Plasma filtration dialysis/Plasma perfusion引用本文复制引用
王丽玉,叶晓玲,石磬..不同模式人工肝治疗对肝衰竭患者肝肾功能及凝血功能的影响[J].中国医学创新,2024,21(18):45-49,5.基金项目
江西省中医药管理局科技计划(2022A042) （2022A042）
