肿瘤血管异常化的基础研究与临床应用进展OA北大核心CSTPCD

The formation of pathological vessels in tumors can mediate a hypoxic and highly permeable tumor microenvironment;thereby promoting the occurrence of various malignant biological behaviors of tumors;such as recurrence;metastasis;immune suppression;and drug resistance.During the development of tumors;angiogenic factors in the microenvironment;such as vascular endothelial growth factor(VEGF)and angiopoietin(Ang);are released in large quantities.These factors stimulate the proliferation and breakthrough of surrounding normal vessels;forming a vascular network that is more fragile;unstable;and prone to bleeding and leakage than normal vessels;thus promoting tumor growth and spread.Therefore;understanding and intervening in the mechanisms of abnormal tumor angiogenesis can provide new ideas and methods for tumor treatment.Although anti-angiogenic therapy;which blocks tumor vessel formation to reduce tumor blood supply and nutrition;has achieved certain success in tumor treatment;the limitations of applicable tumor types and potential side effects and drug resistance have extent somewhat restricted its universal clinical application.Research results show that improving the structure and function of tumor vessels can increase the efficiency of oxygen and drug delivery and enhance immune cell infiltration.This strategy of promoting vascular repair and normalization is currently a hot topic in tumor research and clinical treatment.