中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(3)：203-212,10.DOI:10.3969/j.issn.1674-2591.2024.03.002
男性2型糖尿病患者血清白蛋白水平与骨密度关系的研究
Correlation between serum albumin level and bone mineral density in male patients with type 2 diabetes
摘要
Abstract
Objective To investigate the correlation between serum albumin(ALB)level and bone mineral density(BMD)in male patients with type 2 diabetes mellitus(T2DM)over 50 years old.Methods Totally 202 male T2DM patients over 50 years old hospitalized in the Department of Endocrinology of The First Hospital of Lanzhou Univer-sity and 30 male healthy controls from the physical examination center were selected from July 2021 to March 2022,and the T2DM patients were divided into three groups according to the level of serum ALB.Group T1 was low serum ALB lev-el group(serum ALB level＜40.0 g/L).Patients with normal serum ALB level were divided into two groups by the di-chotomy as T2 group(serum ALB level 40.0-43.3 g/L)and T3 group(serum ALB level 43.4-51.0 g/L).The BMD levels in various parts of body and the prevalence of osteoporosis(OP)/osteopenia among the three groups were com-pared,Pearson correlation analysis was used to analyze the correlation between serum ALB and BMD,and multiple lin-ear regression analysis was used to analyze the independent correlation between serum ALB level and BMD.Results The BMD at total hip and the second to fourth lumbar vertebrae(L2-L4)in the T3 group were significantly higher than those in the T1 group(all P＜0.05).The BMD at L2-L4 in the T2 group was significantly higher than that in the T1 group(P＜0.05).The prevalence of OP and osteopenia in L2-L4 in the T3 group were significantly lower than that of T1 group(8.9%vs.25.0%,P＜0.05).Serum ALB levels were positively correlated with BMD at total hip and L2-L4(r=0.204,0.143;all P＜0.05).Multiple linear regression analysis showed that after adjusting for age,body mass in-dex(BMI),estimated glomerular filtration rate(eGFR),serum free triiodothyronine(FT3),thyroid-stimulating hor-mone(TSH),γ-glutamyl transferase(GGT),lactate dehydrogenase(LDH),creatine kinase(CK),aspartate trans-aminase(AST),glycosylated hemoglobin(HbA1c),calcium(Ca),phosphorus(P),uric acid(UA),and urinary albumin excretion rates(UAER),serum ALB level was independently and positively correlated with BMD at total hip(β=0.229,95%CI:0.000-0.019).Conclusion Serum ALB level is closely related to BMD of male T2DM pa-tients over 50 years old,and middle-aged and elderly male T2DM patients should pay attention to changes in serum ALB level which could provide clues for osteoporosis prevention and treatment.关键词
2型糖尿病/骨质疏松/血清白蛋白/骨密度Key words
diabetes mellitus type 2/osteoporosis/serum albumin/bone mineral density分类
医药卫生引用本文复制引用
韩梅,昝晓晖,马邓荣,郭馨远,赵阳婷,李凯,陈重阳,王亚雯,刘靖芳..男性2型糖尿病患者血清白蛋白水平与骨密度关系的研究[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(3):203-212,10.基金项目
国家自然科学基金(82360161、81960155) （82360161、81960155）
甘肃省兰州市科技计划项目(2022-3-46) （2022-3-46）
兰州大学第一医院院内基金(ldyyyn2020-01) （ldyyyn2020-01）
