摘要
Abstract
Objective:To observe the effects of Sivelestat Sodium in the treatment of sepsis associated with acute respiratory distress syndrome(ARDS).Method:A total of 60 patients with sepsis associated with ARDS admitted to People's Hospital of Yangjiang from June to December 2023 were divided into two groups by random number table method,with 30 cases in each group.One group was treated with conventional treatment as the control group,while the other group was treated with conventional treatment combined with Sivelestat Sodium as the study group,they were treated for 7 d.The serological parameters(inflammation indicators,platelet count,blood gas index),acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score,lung injury score,sequential organ failure assessment(SOFA)score,and the time of mechanical ventilation and mortality of the two groups were compared.Result:Before treatment,there were no statistically significant differences between the two groups in terms of the inflammation indicators,blood gas indexes,platelet count,APACHEⅡ score,lung injury score and SOFA score(P>0.05);after treatment,the levels of serum inflammatory indicators,arterial carbon dioxide pressure,APACHEⅡscore,lung injury score and SOFA score in both groups significantly decreased compared to those before treatment,and those in the study group were lower than those in the control group;arterial oxygen saturation and platelet counts were increased compared to those before treatment,and those in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).The time of mechanical ventilation in the study group was shorter than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the 14 day mortality rate between the two groups(P>0.05).Conclusion:Patients with sepsis with ARDS treated with Sivelestat Sodium,it can significantly reduce the levels of serum inflammation indicators,improve blood gas index,reduce lung injury,shorten the mechanical ventilation time of patients,and the effect is ideal.关键词
西维来司他钠/脓毒症伴急性呼吸窘迫综合征/血清炎症指标/急性生理和慢性健康状况Ⅱ/序贯器官衰竭评分/机械通气Key words
Sivelestat Sodium/Sepsis with acute respiratory distress syndrome/Serum inflammatory indicators/Acute physiology and chronic health evaluation Ⅱ/Sequential organ failure assessment/Mechanical ventilation
