中国中医药信息杂志2024，Vol.31Issue(7)：25-31,7.DOI:10.19879/j.cnki.1005-5304.202307439
基于数据挖掘的急性痛风性关节炎中医用药规律研究
Study on TCM Medication Law in Acute Gouty Arthritis Based on Data Mining
摘要
Abstract
Objective To explore the characteristics of TCM prescriptions for acute gouty arthritis based on data mining methods;To provide reference for clinical treatment.Methods The clinical literature on the TCM treatment of acute gouty arthritis was retrieved from CNKI,Wanfang Data,VIP and SinoMed.The obtained formulas were input into Excel 2019 to establish a database,and SPSS Modeler 18.0,SPSS Statistics 26.0 and Cytoscape 3.9.1 were used for frequency analysis,association rule analysis,clustering analysis and factor analysis.Results A total of 290 articles meeting the requirements were included,including 295 prescriptions,involving 218 kinds of Chinese materia medica,with a total frequency of 3 573 times.24 kinds of Chinese materia medica,including Coicis Semen,Phellodendri Chinensis Cortex,Atractylodis Rhizoma,Smilacis Glabrae Rhizoma,Dioscoreae Spongiosae Rhizoma,Glycyrrhizae Radix et Rhizoma,Achyranthis Bidentatae Radix were used frequently in the treatment of acute gouty arthritis.The commonly used drugs were heat-clearing drugs,moisture-clearing drugs,blood circulation-activating drugs for removing blood stasis,and wind-dampness drugs.The property was mainly cold,the taste was mainly bitter,and the meridians were mainly liver,stomach,spleen and kidney meridians.The analysis of high-frequency drug association rules obtained 22 drug combinations,among which the core drug pairs were Phellodendri Chinensis Cortex-Atractylodis Rhizoma,Coicis Semen-Atractylodis Rhizoma-Phellodendri Chinensis Cortex.Clustering analysis obtained 4 clustering methods,and factor analysis obtained 9 common factors.Conclusion The main treatment of acute gouty arthritis by TCM is clearing heat and dampness,removing blood stasis and clearing collaterals,tonifying liver and kidney,regulating spleen and stomach,which could provide reference for the clinical treatment of acute gouty arthritis.关键词
急性痛风性关节炎/数据挖掘/用药规律/中医Key words
acute gouty arthritis/data mining/medication law/TCM分类
医药卫生引用本文复制引用
吴琴,张亚男,刘艺璇,蔡昱哲,陈静,阳晶晶,罗政,邓奕辉..基于数据挖掘的急性痛风性关节炎中医用药规律研究[J].中国中医药信息杂志,2024,31(7):25-31,7.基金项目
国家重点研发计划(2022YFC3501200、2022YFC3501202) （2022YFC3501200、2022YFC3501202）
湖南省科技创新团队项目(2020RC4050) （2020RC4050）
湖南中医药大学研究生创新课题(2023CX27) （2023CX27）
