原发性甲状旁腺功能亢进症合并意义未明单克隆丙种球蛋白血症一例报告及文献复习OA北大核心CSTPCD
Primary hyperparathyroidism with monoclonal gammopathy of undetermined significance:a case report and literature review
原发性甲状旁腺功能亢进症(primary hyperparathyroidism,PHPT)是内分泌常见疾病,但合并意义未明单克隆丙种球蛋白血症(monoclonal gammopathy of undetermined significance,MGUS)的报道较少.本文报道一例 55 岁女性,临床表现为逐渐加重的腰背部疼痛.辅助检查提示甲状旁腺激素(parathyroid hormone,PTH)升高、高钙血症和低磷血症.颈部超声造影和甲状旁腺放射性核素显像均提示甲状腺右侧叶下极下方实性结节.术后病理诊断甲状旁腺腺瘤.免疫固定电泳提示IgA λ型M蛋白增高,结合骨髓涂片等诊断为MGUS.
Primary hyperparathyroidism(PHPT)is a common endocrine disease,but PHPT complicated with monoclonal gammopathy of undetermined significance(MGUS)is rarely reported.In this article,a case of a 55-year-old woman presented with progressively aggravated skeletal pain was reported.Laboratory examination revealed high parathyroid hormone(PTH),hypercalcemia and hypophosphoremia.Contrast-enhanced ultrasonography and radionuclide imaging of the parathyroid gland revealed solid nodulations below the right inferior pole of the thyroid gland.Postoperative pathological diagnosis was parathyroid adenoma.M protein of IgA λ was detected by immunofixation electrophoresis.Com-bined with bone marrow smear,monoclonal gammopathy of undetermined significance(MGUS)was diagnosed.
苏静;李志辉;卢春燕
610041 成都,四川大学华西医院内分泌代谢科||618200 四川绵竹,四川省绵竹市人民医院内分泌代谢科610041 成都,四川大学华西医院甲状腺外科610041 成都,四川大学华西医院内分泌代谢科
临床医学
原发性甲状旁腺功能亢进症意义未明单克隆丙种球蛋白血症甲状旁腺腺瘤
primary hyperparathyroidismmonoclonal gammopathy of undetermined significanceparathy-roid adenoma
《中华骨质疏松和骨矿盐疾病杂志》 2024 (003)
240-245 / 6
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