中国中医药信息杂志2024，Vol.31Issue(7)：44-49,6.DOI:10.19879/j.cnki.1005-5304.202310007
基于国家专利的中药治疗癫痫组方规律数据挖掘研究
Data Mining Study on the Prescription Law of TCM for the Treatment of Epilepsy Based on National Patent Database
摘要
Abstract
Objective To explore the prescription law of Chinese materia medica for the treatment of epilepsy based on National Patent Database;To provide references for clinical treatment.Methods Patent data on TCM compounds for treating epilepsy that met the inclusion criteria were collected from the establishment of the Chinese Patent Publication Announcement Network until August 21,2023.Excel 2021 was used to establish the database of prescription medication.Python,SPSS Modeler 18.0,Cytoscape 3.10.1,and R language software were used to model prescription data,analyze medication frequency,conduct complex network analysis,association rule analysis,clustering analysis,to explore the prescription law.Results A total of 376 patents meeting the criteria for epilepsy were included,involving 827 kinds of Chinese materia medica,with a total frequency of 4 911 times.Gastrodiae Rhizoma,Acori Tatarinowii Rhizoma,Bombyx Batryticatus,Scorpio,Uncariae Ramulus cum Uncis were among the top five frequently used Chinese materia medica.The high-frequency drug efficacy categories were primarily liver soothing and wind alleviating drugs,tranquilizers,and phlegm resolving,cough suppressing,and asthma alleviating drugs.The predominant medicinal properties were mild,warm and cold,while the predominant tastes were sweet,pungent and bitter.The herbs were classified under the liver,heart,lung and spleen meridians.The core complex network of Chinese materia medica was identified,and the core combination was Gastrodiae Rhizoma-Acori Tatarinowii Rhizoma-Bombyx Batryticatus.The association rule analysis identified 28 commonly used medicinal combinations,with the highest support being observed for Scorpio-Bombyx Batryticatus.Clustering analysis yields four sets of data.Similarity analysis revealed the unique properties of the patented compound in the treatment of epilepsy.Conclusion The high-frequency drugs and commonly used drug combinations of TCM compounds for treating epilepsy,as disclosed on the Chinese Patent Publication Announcement Network,are primarily aimed at calming wind and stopping convulsions,as well as resolving phlegm and opening the orifices,which can provide reference for clinical practice.关键词
癫痫/中药复方/专利/数据挖掘/用药规律Key words
epilepsy/TCM compound/patent/data mining/medication law分类
医药卫生引用本文复制引用
林蓉,高旅,肖亚楠,黄爽,尚菁,史正刚..基于国家专利的中药治疗癫痫组方规律数据挖掘研究[J].中国中医药信息杂志,2024,31(7):44-49,6.基金项目
国家自然科学基金(82305318) （82305318）
山西省应用基础研究计划(201901D211536) （201901D211536）
山西中医药大学博士科研启动基金(2022BK05) （2022BK05）
山西中医药大学优秀博士毕业生来晋工作奖励经费科研启动基金(2021BKS06) （2021BKS06）
山西中医药大学科技创新能力培育计划"基础研究专项"(2020PY-JC-05) （2020PY-JC-05）
