唑来膦酸注射液可能致横纹肌溶解综合征一例报告OA北大核心CSTPCD

Zoledronic acid is the first-line drug for the clinical treatment of osteoporosis.Rhabdomyolysis is rarely occurred after zoledronic acid use.In this article,an elderly woman with osteoporosis was reported of rhabdomyolysis with hepatic and renal dysfunction after zoledronic acid treatment.The causal relationship between zoledronic acid and the oc-currence of rhabdomyolysis was possible judged with Naranjo's algorithm for adverse drug reaction scale.The pathogenesis may be related to hypophosphatemia induced by zoledronic acid,which could lead to impaired oxidative phosphorylation in tissue cells and severe hypoxia and ischemia in tissues and organs due to damage of erythrocyte storage.The onset and management process of this rare case were reported in detail and the prevention and treatment strategies for this particular condition were discussed.