中华骨质疏松和骨矿盐疾病杂志2024，Vol.17Issue(3)：252-258,7.DOI:10.3969/j.issn.1674-2591.2024.03.008
唑来膦酸注射液可能致横纹肌溶解综合征一例报告
Rhabdomyolysis caused by zoledronic acid:a case report
摘要
Abstract
Zoledronic acid is the first-line drug for the clinical treatment of osteoporosis.Rhabdomyolysis is rarely occurred after zoledronic acid use.In this article,an elderly woman with osteoporosis was reported of rhabdomyolysis with hepatic and renal dysfunction after zoledronic acid treatment.The causal relationship between zoledronic acid and the oc-currence of rhabdomyolysis was possible judged with Naranjo's algorithm for adverse drug reaction scale.The pathogenesis may be related to hypophosphatemia induced by zoledronic acid,which could lead to impaired oxidative phosphorylation in tissue cells and severe hypoxia and ischemia in tissues and organs due to damage of erythrocyte storage.The onset and management process of this rare case were reported in detail and the prevention and treatment strategies for this particular condition were discussed.关键词
唑来膦酸/双膦酸盐类/横纹肌溶解综合征/骨质疏松症Key words
zoledronic acid/bisphosphonates/rhabdomyolysis/osteoporosis引用本文复制引用
曾施琪,翟琳娜,陈文辉..唑来膦酸注射液可能致横纹肌溶解综合征一例报告[J].中华骨质疏松和骨矿盐疾病杂志,2024,17(3):252-258,7.基金项目
国家自然科学基金地区科学基金(8236140250) （8236140250）
