中国医院用药评价与分析2024，Vol.24Issue(6)：651-654,4.DOI:10.14009/j.issn.1672-2124.2024.06.003
阿伐那非联合助阳活血方治疗勃起功能障碍的临床研究
Clinical Study on Avanafil Combined with Zhuyang Huoxue Formula in the Treatment of Erectile Dysfunction
摘要
Abstract
OBJECTIVE:To probe into the efficacy and safety of avanafil combined with Zhuyang Huoxue formula in the treatment of erectile dysfunction.METHODS:A total of 108 patients with erectile dysfunction admitted into Gansu Provincial Maternal and Child Care Hospital from Jun.2022 to May 2023 were selected and randomly divided into control group(54 cases)and observation group(54 cases)by random number table method.The control group was given Avanafil tablets,while the observation group was given Zhuyang Huoxue formula based on the control group.The clinical efficacy and incidences of adverse drug reactions were compared between two groups,the erectile hardness score(EHS),international index of erectile dysfunction(IIEF-5)and nocturnal erectile function were compared between two groups before and after treatment.RESULTS:The total effective rate of the observation group was 92.59%(50/54),higher than 77.78%(42/54)of the control group,with statistically significant difference(P<0.05).After treatment,the EHS and IIEF-5 scores of both groups were higher than those before treatment,and the observation group was higher than the control group,with statistically significant differences(P<0.05).After treatment,the total duration of nocturnal erection,duration of root hardness≥60%and duration of head hardness≥60%of both groups were longer than those before treatment,the number of erections,root circumference change ratio and head circumference change ratio of both groups were higher than those before treatment;and the total duration of nocturnal erection,duration of root hardness≥60%and duration of head hardness≥60%of the observation group were longer than those of the control group,the number of erection,root circumference change ratio and head circumference change ratio of the observation group were higher than those of the control group,with statistically significant differences(P<0.05).The incidence of adverse drug reactions of the observation group was 11.11%(6/54),while the control group was 12.96%(7/54),the difference was not statistically significant(P>0.05).CONCLUSIONS:The clinical efficacy of avanafil combined with Zhuyang Huoxue formula in the treatment of erectile dysfunction is remarkable,which can effectively improve the erectile function,with good safety.关键词
勃起功能障碍/阿伐那非/助阳活血方/疗效Key words
Erectile dysfunction/Avanafil/Zhuyang Huoxue formula/Efficacy分类
医药卫生引用本文复制引用
王志强,关雁,刘春辉,孙大林,陕文生..阿伐那非联合助阳活血方治疗勃起功能障碍的临床研究[J].中国医院用药评价与分析,2024,24(6):651-654,4.基金项目
国家自然科学基金资助项目(No.81874472) （No.81874472）
