中国医院用药评价与分析2024，Vol.24Issue(6)：662-666,671,6.DOI:10.14009/j.issn.1672-2124.2024.06.005
基于网络药理学研究柴胡-白芍治疗宫颈高危型人乳头状瘤病毒感染的作用机制
Mechanisms of Radix Bupleuri-Radix Paeoniae Alba in the Treatment of Cervical High-Risk Human Papilloma Virus Infection Base on Network Pharmacology
摘要
Abstract
OBJECTIVE:To probe into the core drug pairs of traditional Chinese medicine(TCM)in the treatment of cervical high-risk human papilloma virus(HPV)infections by using data mining methods,and to clarify the mechanism of the core drug pairs by network pharmacology methods.METHODS:Related literature were retrieved from CNKI,Wanfang Data and VIP database to screen out core drug pairs.The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was retrieved for the relevant active ingredients and targets of core drug pairs;the On-Line Mendelian Inheritance in Man and GeneCards databases were retrieved for disease-related targets.Cytoscape 3.9.1 software was used to construct core targets network.DAVID database was used to perform gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis on the targets.RESULTS:A total of 216 studies,209 prescriptions and 194 kinds of traditional Chinese medicine were enrolled,the core drug pair of Radix bupleuri-Radix paeoniae aba was obtained.A total of 15 active ingredients and 433 targets in Radix bupleuri as well as 9 active ingredients and 161 targets in Radix paeoniae alba were screened out,and 297 targets remained after deduplication;there were 116 intersection targets with disease.The core targets of Radix bupleuri-Radix paeoniae alba for the treatment of cervical high-risk HPV infection included protein kinase B(Akt)1,tumour necrosis factor,interleukin 6 and PPARG.The mechanism of action was mainly exerted through the cancer pathway,phosphatidylinositol 3 kinase-Akt signaling pathway,etc.;the biological processes involved mainly included the positive regulation of gene expression and the negative regulation of apoptotic process,etc.CONCLUSIONS:This study preliminarily verifies that Radix bupleuri-Radix paeoniae alba can participate into the inflammatory response and immune regulation through multi-targets and multi-pathways,so as to achieve the therapeutic effect of cervical high-risk HPV infection.关键词
宫颈高危型人乳头状瘤病毒感染/柴胡/白芍/网络药理学/作用机制Key words
Cervical high-risk human papilloma virus infection/Radix bupleuri/Radix paeoniae alba/Network pharmacology/Mechanism分类
医药卫生引用本文复制引用
朱梓齐,秦琴琴,辛幸雨,宁雪梅,林寒梅..基于网络药理学研究柴胡-白芍治疗宫颈高危型人乳头状瘤病毒感染的作用机制[J].中国医院用药评价与分析,2024,24(6):662-666,671,6.基金项目
国家自然科学基金地区科学基金项目(No.82160919) （No.82160919）
全国名中医陈慧侬学术思想与临床诊疗传承发展推广中心(No.04B23008V3) （No.04B23008V3）
