前列腺素E2在骨形成中的作用机制OA北大核心CSTPCD
Mechanism of prostaglandin E2 in bone formation
前列腺素E2(prostaglandin E2,PGE2)作为体内一种重要的生物活性物质,通过作用于前列腺素E受体(prostaglandin E receptor,EP),参与内环境稳态的维持.PGE2 在骨代谢调控中发挥重要作用,在骨重建的过程中,调控成骨细胞介导的骨形成与破骨细胞介导的骨吸收,维持动态平衡.在骨形成方面,PGE2/EP轴通过神经调控、机械负荷调控、与体内其他细胞分子间的交互作用,促进成骨细胞增殖分化,维持骨稳态.因此,PGE2 在以骨量异常为特征的疾病中发挥关键作用,可能是潜在的治疗靶点.本文对近年来PGE2 在骨形成中的调控机制进行综述,并总结现有的临床应用.
Prostaglandin E2(PGE2),as an important bioactive substance in vivo,participates in the homeosta-sis maintenance by acting on the prostaglandin E receptor(EP)and plays an important role in the regulation of bone me-tabolism.In the process of bone remodeling,PGE2 maintains the balance between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts.In bone formation,the PGE2/EP axis promotes osteoblast proliferation and differentiation and maintains bone homeostasis through neural modulation,mechanical loading,and interactions with other cellular molecules.Therefore,PGE2 plays a pivotal role in diseases characterized by abnormal bone mass,which means it maybe serve as the potential therapeutic target.This review summarized the regulatory mechanisms of PGE2 in bone forma-tion and its clinical applications.
周若彤;庞倩倩;夏维波
100730 北京,中国医学科学院 北京协和医学院 北京协和医院内分泌科
临床医学
前列腺素E2骨形成神经调控机械负荷成骨细胞
prostaglandin E2bone formationneural modulationmechanical loadingosteoblast
《中华骨质疏松和骨矿盐疾病杂志》 2024 (003)
295-302 / 8
国家重点研发计划(2021YFC2501704);国家自然科学基金(82270938,82200993);中央高水平医院临床科研业务费资助项目(2022-PUMCH-D-006,2022-PUMCH-B-014);
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