摘要
Abstract
OBJECTIVE:To probe into the effects of minimally invasive thoracic catheterization assisted with urokinase combined with dexamethasone on serum T lymphocyte related cytokines and fibrinolytic activity in patients with tuberculous pleurisy.METHODS:A total of 90 patients with tuberculous pleurisy admitted into the hospital from Apr.2019 to Apr.2023 were extracted to be divided into the dexamethasone group and combined group via the random number table method,with 45 cases in each group.Patients in the dexamethasone group were treated with minimally invasive thoracic catheterization assisted with dexamethasone,while the combined group received minimally invasive thoracic catheterization assisted with urokinase combined with dexamethasone.The improvement of clinical symptoms and pleural thickness of two groups were compared.Levels of lung function[maximum expiratory flow(MEF),forced vital capacity(FVC)and forced expiratory volume in one second(FEV1)],hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor(TNF-α),T lymphocyte CD4+and CD3+,tissue type plasminogen activator(t-PA)/plasminogen activator inhibitor 1(PAI-1)and type Ⅲ procollagen(PC-Ⅲ)levels of two groups were detected,the therapeutic effects of two groups were compared.RESULTS:The disappearance time of chest tightness,pleural effusion and fever in combination group was shorter than that in dexamethasone group,and the pleural thickness was lower than that in dexamethasone group,with statistically significant differences(P<0.05).After treatment,the levels of MEF,FVC and FEV1 in combined group were higher than those in dexamethasone group,the levels of hs-CRP,TNF-α and PC-Ⅲ were lower than those in dexamethasone group,and the levels of CD4+,CD3+and t-PA/PAI-1 were higher than those in dexamethasone group,with statistically significant differences(P<0.05).The total effective rate of combined group was 95.56%(43/45),higher than 80.00%(36/45)of dexamethasone group,the difference was statistically significant(P<0.05).CONCLUSIONS:The efficacy of minimally invasive thoracic catheterization assisted with urokinase combined with dexamethasone in the treatment of patients with tuberculous pleurisy is significant,which can effectively reduce the clinical symptoms,improve lung function,reduce inflammation,and improve immune function and fibrinolytic activity.关键词
结核性胸膜炎/胸腔微创置管/尿激酶/地塞米松/纤溶活性/免疫功能Key words
Tuberculous pleurisy/Minimally invasive thoracic catheterization/Urokinase/Dexamethasone/Fibrinolytic activity/Immune function分类
药学
