中国医院用药评价与分析2024，Vol.24Issue(6)：726-730,5.DOI:10.14009/j.issn.1672-2124.2024.06.020
沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的疗效及安全性的系统评价与Meta分析
Systematic Review and Meta-Analysis on Efficacy and Safety of Modified Shashen Maidong Decoction Combined with Azithromycin in the Treatment of Mycoplasma Pneumonia in Children
摘要
Abstract
OBJECTIVE:To systematically evaluate the clinical efficacy and safety of modified Shashen Maidong decoction combined with azithromycin in the treatment of Mycoplasma pneumonia in children.METHODS:CNKI,Wanfang Data,VIP,CBM,PubMed,Embase,Web of Science and other Chinese and English databases were retrieved to collect randomized controlled trial of modified Shashen Maidong decoction combined with azithromycin in the treatment of Mycoplasma pneumonia in children(observation group was treated with modified Shashen Maidong decoction combined with azithromycin,while control group received azithromycin),the retrieval time was from the database establishment to Oct.2023.After literature screening and data extraction,Meta-analysis was conducted on the included studies.RESULTS:A total of 13 studies including 1144 patients were enrolled.Meta-analysis showed that compared with the control group,modified Shashen Maidong decoction combined with azithromycin could effectively improve the total clinical effective rate of children with Mycoplasma pneumonia(OR=5.65,95%CI=3.56-8.97,P<0.00001)and shorten fever remission time(MD=-2.88,95%CI=-5.11--0.64,P=0.01),cough disappearance time(MD=-2.78,95%CI=-4.63--0.94,P=0.003)and lung rale disappearance time(MD=-2.91,95%CI=-4.27--1.54,P<0.0001),decreased the recurrence rate(OR=0.21,95%CI=0.07-0.63,P=0.005),and the incidence of adverse drug reactions(OR=0.21,95%CI=0.12-0.37,P<0.00001),the differences were statistically significant.CONCLUSIONS:Shashen Maiodong decoction combined with azithromycin has certain advantages in the treatment of Mycoplasma pneumonia in children,which can improve clinical efficacy and decrease incidence of adverse drug reactions,but the conclusion still needs to be confirmed by high-quality,large sample and multi-center randomized controlled trials.关键词
沙参麦冬汤/阿奇霉素/小儿支原体肺炎/有效性/Meta分析Key words
Shashen Maidong decoction/Azithromycin/Mycoplasma pneumonia in children/Efficacy/Meta-analysis分类
医药卫生引用本文复制引用
李国英,陈良,刘远婷..沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的疗效及安全性的系统评价与Meta分析[J].中国医院用药评价与分析,2024,24(6):726-730,5.基金项目
新疆维吾尔自治区青年科技人才项目(No.WJWY-XCZX202219) （No.WJWY-XCZX202219）
