沙参麦冬汤加减方联合阿奇霉素治疗小儿支原体肺炎的疗效及安全性的系统评价与Meta分析OACSTPCD

OBJECTIVE:To systematically evaluate the clinical efficacy and safety of modified Shashen Maidong decoction combined with azithromycin in the treatment of Mycoplasma pneumonia in children.METHODS:CNKI,Wanfang Data,VIP,CBM,PubMed,Embase,Web of Science and other Chinese and English databases were retrieved to collect randomized controlled trial of modified Shashen Maidong decoction combined with azithromycin in the treatment of Mycoplasma pneumonia in children(observation group was treated with modified Shashen Maidong decoction combined with azithromycin,while control group received azithromycin),the retrieval time was from the database establishment to Oct.2023.After literature screening and data extraction,Meta-analysis was conducted on the included studies.RESULTS:A total of 13 studies including 1144 patients were enrolled.Meta-analysis showed that compared with the control group,modified Shashen Maidong decoction combined with azithromycin could effectively improve the total clinical effective rate of children with Mycoplasma pneumonia(OR=5.65,95%CI=3.56-8.97,P<0.00001)and shorten fever remission time(MD=-2.88,95%CI=-5.11--0.64,P=0.01),cough disappearance time(MD=-2.78,95%CI=-4.63--0.94,P=0.003)and lung rale disappearance time(MD=-2.91,95%CI=-4.27--1.54,P<0.0001),decreased the recurrence rate(OR=0.21,95%CI=0.07-0.63,P=0.005),and the incidence of adverse drug reactions(OR=0.21,95%CI=0.12-0.37,P<0.00001),the differences were statistically significant.CONCLUSIONS:Shashen Maiodong decoction combined with azithromycin has certain advantages in the treatment of Mycoplasma pneumonia in children,which can improve clinical efficacy and decrease incidence of adverse drug reactions,but the conclusion still needs to be confirmed by high-quality,large sample and multi-center randomized controlled trials.