中国医院用药评价与分析2024，Vol.24Issue(6)：743-747,5.DOI:10.14009/j.issn.1672-2124.2024.06.023
360例住院患者氨基糖苷类抗感染药物使用情况分析
Application of Aminoglycoside Anti-Infective Drugs in 360 Inpatients
摘要
Abstract
OBJECTIVE:To investigate the application of aminoglycoside anti-infective drugs in inpatients,so as to promote rational drug use in clinic.METHODS:Demographic data,drug administration,pathogen examination,drug combination,and adverse drug reactions of inpatients with systemic aminoglycosides anti-infective drugs in the hospital from Jan.1st to Jun.1st,2023 were retrospectively analyzed.RESULTS:A total of 360 inpatients were treated with amikacin,etimicin,and gentamicin during this period.There were 251 male patients and 109 female patients with an average age of(60.39±18.11)years.Aminoglycoside anti-infective drugs were mainly used in the treatment of Gram-negative bacterial infection,and were mostly combined with β-lactam drugs.Among 202 patients treated with medication,the effective rate was 91.09%(184/202).Serum creatinine of 25 patients increased significantly after treatment(6.94%).Totally 133 patients had irrational medication,including 24 cases of irrational dosage(18.05%),39 cases of improper drug combination(29.32%),52 cases of irrational prophylactic medication regimen(39.10%),25 cases of irrational timing of perioperative medication(18.80%),and 12 cases of irrational selection of prophylactic medication(9.02%).CONCLUSIONS:The clinical application of aminoglycoside anti-infective drugs in the hospital is generally rational,yet there are still some problems such as inaccurate dosage and irrational drug combination.Rational medication should be guided by therapeutic drug monitoring,and the changes of related indicators of renal function should be paid close attention during drug use.关键词
氨基糖苷类药物/抗感染药物/合理用药/回顾性分析Key words
Aminoglycoside/Anti-infective drugs/Rational medication/Retrospective analysis分类
医药卫生引用本文复制引用
付观双,周维英,蔡芸,梁蓓蓓,沈正泽..360例住院患者氨基糖苷类抗感染药物使用情况分析[J].中国医院用药评价与分析,2024,24(6):743-747,5.基金项目
重庆市临床药学重点专科建设项目(No.渝卫办[2023]69号) （No.渝卫办[2023]69号）
重庆医科大学未来医学青年创新团队支持项目(No.W0067) （No.W0067）
