中国医院用药评价与分析2024，Vol.24Issue(6)：761-763,768,4.DOI:10.14009/j.issn.1672-2124.2024.06.027
替加环素对凝血功能影响的回顾性分析
Retrospective Analysis on Effect of Tigecycline on Coagulation Function
摘要
Abstract
OBJECTIVE:To explore the effects of tigecycline on coagulation function and liver function.METHODS:Clinical data of 55 patients receiving anti-infective treatment with tigacycline in Beijing Friendship Hospital,Capital Medical University from Jan.2019 to Jun.2022 were collected.Levels of coagulation function indicators including peripheral blood fibrinogen(FIB),activated partial thrombin time(APTT),international normalized ratio(INR),D-dimer and platelet count(PLT)were recordedbefore medication(T0),7 d after medication(T7)and at the end of medication(Tf).The levels of liver function indicators in T0,T7 and Tf were recorded,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and albumin(ALB).The coagulation function and liver function indicators were statistically analyzed.RESULTS:After treatment with tigecycline,the FIB level of patients showed a decreasing trend,and the FIB level of T7 and Tf was lower than that of T0,with statistically significant difference(P<0.05);the APTT of T7 and Tf was longer than that of T0,the difference was statistically significant(P<0.05);the D-dimer level showed a decreasing trend,and the D-dimer level of Tf was lower than that of T0,with statistically significant difference(P<0.05),suggesting that tigecycline had some effects on coagulation function.After treatment with tigecycline,ALT levels of T7 and Tf were lower than those of T0,the difference was statistically significant(P<0.05),showing a decreasing trend;the levels of ALP,AST,TBIL and ALB in T7 and Tf were not significantly different from those in T0,without statistically significant differences(P>0.05),suggesting that tigecycline had no effect on liver function.CONCLUSIONS:Tigecycline may cause a decrease in FIB levels,prolongation of APTT,and a decrease in D-dimer levels,and patients'coagulation needs to be closely monitored during administration to prevent bleeding.关键词
替加环素/凝血功能障碍/纤维蛋白原Key words
Tigecycline/Coagulation dysfunction/Fibrinogen分类
医药卫生引用本文复制引用
刘莲,王晓剑,郭明星,刘冉佳,何超然,赵莹,崔向丽..替加环素对凝血功能影响的回顾性分析[J].中国医院用药评价与分析,2024,24(6):761-763,768,4.基金项目
北京友谊医院科研启动基金项目(No.yygdktgl2021-3) （No.yygdktgl2021-3）
