中国合理用药探索2024，Vol.21Issue(6)：1-6,6.DOI:10.3969/j.issn.2096-3327.2024.06.001
叶酸联合维生素B12与二甲双胍对2型糖尿病患者的疗效分析
Analysis of Folic Acid Combined with Vitamin B12 Plus Metformin in the Treatment of Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To investigate the therapeutic effect of folic acid combined with vitamin B12(VB12)and metformin in patients with type 2 diabetes mellitus(T2DM).Methods:112 T2DM patients admitted to a certain hospital from February 2019 to March 2021 were selected as the study subjects.They were randomly divided into a control group(VB12+metformin,n=56)and an observation group(folic acid+VB12+metformin,n=56)using a random number table method.The blood glucose levels[fasting blood glucose(FBG),2-hour postprandial blood glucose(2hBG)],glycated hemoglobin(HbA1c),fasting insulin(FINS),homeostasis model assessment-insulin resistance(HOMA-IR),homocysteine(Hcy),as well as Th1,Th17,Th1/Th17 levels were compared between the two groups.And compare the clinical efficacy,adverse reactions,and incidence of complications between the two groups.Results:After treatment,the FBG,2hBG,HOMA-IR,HbA1c,FINS,and Hcy of both groups of patients were lower than before treatment,and were lower in the observation group than those in the control group(P<0.05);the levels of Th1 and Th17 were lower than before treatment,and were lower in the observation group was lower than those in the control group(P<0.05);Th1/Th17 was higher than before treatment,and was higher in the observation group was higher than that in the control group(P<0.05).The total effective rate of clinical treatment in the observation group was higher than that in the control group(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05);the incidence of complications in the observation group was lower than that in the control group(P<0.05).Conclusion:Combination of folic acid with VB12 and metformin has a definite therapeutic effect on T2DM patients,which can effectively regulate Th1/Th17 balance,improve blood glucose and insulin levels,and has high safety.关键词
叶酸/维生素B12/二甲双胍/2型糖尿病/胰岛素抵抗Key words
folic acid/vitamin B12/metformin/type 2 diabetes mellitus/insulin resistance分类
医药卫生引用本文复制引用
王昱,张红瑾,姬劲锐..叶酸联合维生素B12与二甲双胍对2型糖尿病患者的疗效分析[J].中国合理用药探索,2024,21(6):1-6,6.基金项目
2019年度河南省医学科技攻关计划(联合共建)项目(LHGJ20191068) （联合共建）
