中国药业2024，Vol.33Issue(13)：64-68,5.DOI:10.3969/j.issn.1006-4931.2024.13.015
糖皮质激素冲击治疗对慢性肾脏病患者中性粒细胞和白细胞计数的影响
Effect of Glucocorticoids Pulse Therapy on the Neutrophil and White Blood Cell Counts in Patients with Chronic Kidney Disease
摘要
Abstract
Objective To investigate the effect of glucocorticoids pulse therapy(GPT)on neutrophil and white blood cell counts in patients with chronic kidney disease.Methods A total of 76 patients with chronic kidney disease who underwent GPT in the nephrology department of the hospital from January 2018 to December 2022 were selected and divided into the infected group(25 cases)and the uninfected group(51 cases)based on whether they had infection.The patients in the uninfected group were divided into the non-glucocorticoid group(35 cases)and the glucocorticoid group(16 cases)based on whether glucocorticoids were used before GPT.According to the age of the patients,they were divided into the 10-19 years old group(6 cases),20-29 years old group(13 cases),and 40-49 years old group(11 cases).With the neutrophil and white blood cell counts in the last blood routine examination before GPT as the baseline level,the absolute values of neutrophil and white blood cell counts during and after GPT in patients were recorded.Results On the 1st,2nd,and 3rd day of GPT,the neutrophil and white blood cell counts of patients in the uninfected group significantly increased(P<0.05),while there was no significant difference in the infected group(P>0.05).On the 1st day after GPT,the neutrophil and white blood cell counts in the uninfected group and the infected groups decreased to the baseline level(P<0.05).There was no significant difference in the neutrophil and white blood cell counts between the glucocorticoid group and the non-glucocorticoid group on the 3rd day of GPT(P>0.05).The neutrophil and white blood cell counts in the 10-19 year old group on the 3rd day of GPT were significantly higher than those in the 20-29 year old group and the 40-49 year old group(P<0.05).Conclusion GPT can significantly increase neutrophil and white blood cell counts in uninfected patients,and the magnitude of the increase correlated with age but not with pre-GPT glucocorticoid usage.On the 1st day after GPT,the patients' neutrophil and white blood cell counts significantly decreased to the baseline level before GPT.关键词
糖皮质激素/激素冲击治疗/中性粒细胞计数/白细胞计数/感染/年龄Key words
glucocorticoid/pulse therapy/neutrophil count/white blood cell count/infection/age分类
医药卫生引用本文复制引用
曾雪霖,李薇..糖皮质激素冲击治疗对慢性肾脏病患者中性粒细胞和白细胞计数的影响[J].中国药业,2024,33(13):64-68,5.基金项目
重庆市自然科学基金面上项目[cstc2020jcyj-msxmX0337] （）
重庆市沙坪坝区技术创新与应用发展项目[2023117] （）
中山大学附属第七医院2020-2022年度临床科研基金[ZSQYLCKYJJ202012]. （）
