中国合理用药探索2024，Vol.21Issue(6)：64-69,6.DOI:10.3969/j.issn.2096-3327.2024.06.010
坦索罗辛联合输尿管软镜钬激光碎石术对输尿管结石患者结石清除率及氧化应激的影响
Effects of Tamsulosin Combined with Flexible Ureteroscopic Holmium Laser Lithotripsy on Stone Clearance Rate and Oxidative Stress in Patients with Ureteral Calculi
摘要
Abstract
Objective:To investigate the effects of tamsulosin combined with flexible ureteroscopic holmium laser lithotripsy on stone clearance rate and oxidative stress in patients with ureteral calculi.Methods:A total of 100 patients with ureteral calculi treated in a hospital from June 2022 to June 2023 were selected and assigned to the control group and observation group by random number table method,with 50 patients in each group.Both groups were treated with flexible ureteroscopic holmium laser lithotripsy,the control group was given conventional treatment such as hemostasis and anti-infection,and the observation group was given tamsulosin hydrochloride sustained-release capsules in addition to the treatment provided in the control group after surgery.The oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA)and cortisol(Cor)],stone removal(stone removal time,stone-free time,pain score and stone clearance rate),clinical response,recurrence rate and adverse reactions were compared between the two groups.Results:After treatment,the serum MDA and Cor levels were decreased in both groups(P<0.05),and were lower in the observation group than those in the control group(P<0.05).The level of serum SOD was increased in both groups(P<0.05),and was higher in the observation group than that in the control group(P<0.05).The stone removal time and stone-free time in the observation group were earlier than those in the control group(P<0.05),the stone removal-associated pain score in the observation group was lower than that in the control group(P<0.05),and the stone clearance rate in the observation group was higher than that in the control group(P<0.05).The total response rate in the observation group(96.00%)was higher than that in the control group(80.00%,P<0.05).No patients in the observation group had recurrence after treatment,while 7 patients(14.00%)experienced recurrence in the control group.There was statistically significant difference in the recurrence rate between the two groups(χ2=5.530,P=0.019).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ2=0.510,P=0.475).Conclusion:Tamsulosin combined with flexible ureteroscopic holmium laser lithotripsy is effective in the treatment of patients with ureteral calculi as it can significantly improve the stone clearance rate,relieve stone removal-associated pain,and reduce oxidative stress,with low risk of recurrence.关键词
输尿管软镜钬激光碎石术/坦索罗辛/输尿管结石/结石清除率/氧化应激Key words
flexible ureteroscopic holmium laser lithotripsy/tamsulosin/ureteral calculi/stone clearance rate/oxidative stress分类
医药卫生引用本文复制引用
豆亚鹏,胡祥..坦索罗辛联合输尿管软镜钬激光碎石术对输尿管结石患者结石清除率及氧化应激的影响[J].中国合理用药探索,2024,21(6):64-69,6.基金项目
河南省医学科技攻关计划(联合共建)项目(LHGJ20190926) （联合共建）
