神经药理学报2024，Vol.14Issue(2)：26-30,46,6.DOI:10.3969/j.issn.2095-1396.2024.02.005
基于网络药理学方法探讨白芍治疗癫痫的活性成分和作用机制
Exploring the Active Ingredients and Mechanism of Action of Paeoniae Radix Alba in the Treatment of Epilepsy Based on Network Pharmacology Methods
摘要
Abstract
Objective:To explore the active ingredients and mechanism of action of Paeoniae Radix Alba in the treatment of epilepsy through network pharmacology.Methods:Obtain and screen the active ingredients and targets of Paeoniae Radix Alba from the Encyclopedia of Traditional Chinese Medicine database;Collect epilepsy related genes in GeneCards,OMIM,and DisGeNET databases.After taking the intersection of the active ingredient targets of Paeoniae Radix Alba and epilepsy disease targets,a protein interaction network was constructed using the STRING database.Then,visualization analysis was performed using Cytoscape 3.9.1 software.Core targets were screened using the Centiscape 2.2 plugin,and gene ontology functional annotation(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis were performed using the David database,Finally,use Cytoscape 3.9.1 software to construct a drug component target network diagram.Results:There were 158 active ingredient targets in Paeoniae Radix Alba,2398 disease targets in epilepsy,38 intersection genes between Paeoniae Radix Alba and epilepsy,and GO enrichment analysis yielded BP136 entries,CC41 entries,MF49 entries.KEGG analysis revealed 106 pathways.Conclusion:Paeoniae Radix Alba may act on 38 targets such as TNF,Akt1,ALB,and HSP90AA1,inhibiting signaling pathways such as AGE-RAGE and NF kappa B,thereby treating epilepsy in terms of anti-inflammatory effects.关键词
网络药理学/白芍/癫痫/活性成分/作用机制Key words
network pharmacology/Paeoniae Radix Alba/epilepsy/active ingredients/mechanism of action分类
医药卫生引用本文复制引用
夏蕾,尤斯涵,殷宏艳,郝军荣,郭春燕..基于网络药理学方法探讨白芍治疗癫痫的活性成分和作用机制[J].神经药理学报,2024,14(2):26-30,46,6.基金项目
河北省创新创业教育教学改革研究与实践项目(No.2023cxcy159) （No.2023cxcy159）
