组织工程与重建外科杂志2024，Vol.20Issue(3)：293-299,7.DOI:10.3969/j.issn.1673-0364.2024.03.003
基于细胞黏附的不同微结构3D打印多孔生物支架流体力学有限元分析
Fluid mechanics finite element analysis of 3D printed porous biological scaffolds with different microstructures based on cell adhesion
摘要
Abstract
Objective To study the influence of 3D-printed bone scaffolds with different pore morphologies on cell adhesion.Methods Utilizing MSLattice software,four porous structures with different pore morphologies,namely cubic,Hexagon,diamond,and gyroid,were designed.The principles of finite element analysis(FEM)and computational fluid dynamics(CFD)were employed using Siemens Star CCM+software to simulate the fluid flow within the four scaffold structures,model the process of cell adhesion,measure the fluid flow velocity and pressure within the scaffold,as well as the fluid permeability and the thickness of the adhesion layer.Results Upon the passage of fluid through the four types of scaffolds,the pressure gradually diminished.However,due to the relatively regular structure of the scaffolds,the pressure exhibited a gradient distribution.The simulated pressure values before fluid flow through the four types of scaffolds were,in sequence:Gyroid>Cubic>Diamond>Hexagon.Flow velocity:Cubic>Gyroid>Diamond>Hexagon.The permeability of the four types of scaffolds:Diamond>Hexagon>Cubic>Gyroid.Adhesion layer thickness:Gyroid>Hexagon>Cubic>Diamond.Conclusion The fluid mechanics analysis results show that the gyroid scaffold has lower permeability and the highest adhesion layer thickness,which is more conducive to cell adhesion.关键词
有限元/微结构/3D打印/生物支架/细胞黏附/流体力学Key words
Finite element/Microstructure/3D printing/Biological scaffold/Cell adhesion/Fluid mechanics分类
医药卫生引用本文复制引用
吴其右,崔博宇,夏炜,刘亦洪..基于细胞黏附的不同微结构3D打印多孔生物支架流体力学有限元分析[J].组织工程与重建外科杂志,2024,20(3):293-299,7.基金项目
国家自然科学基金(52111530189). （52111530189）
