基于多谱学技术剖析"白转黑"发用产品功效成分OA北大核心CSTPCD

The combination of chromatography,mass spectrometry,spectroscopy,and energy spectrum analysis techniques is used to screen,identify,and confirm the potential functional compo-nents in the"white to black"hair products.High-performance liquid chromatography was used for targeted screening of common hair dyes using.Gas chromatography-mass spectrometry(GC-MS),and ultra-high performance liquid chromatography-high-resolution mass spectrometry(UHPLC-HRMS)were used to screen for potential hair dye and melanogenic components.Under optimized screening conditions,UHPLC-HRMS identified a significant decrease in m/z 147.930 9 after 72 hours of sample placement.Based on accurate mass number,isotope distribution,and retention time,it is inferred that the component is silver ions.The content of silver element and nitrate ion was determined by inductively coupled plasma mass spectrometry and ion chromatography,and its source was analyzed based on the properties of the raw materials.At the same time,the blackening compo-nent of the product was confirmed by low vacuum thermal field emission scanning electron microsco-py,and it was speculated that silver nitrate may be an important reason for the efficacy of the"white to black"product.The"white to black"hair products based on silver nitrate as the active ingredi-ent have significant compliance and safety risks,and there is an urgent need to strengthen supervi-sion of such products.The combination analysis model established in this article will provide techni-cal reference for further in-depth analysis of cosmetic safety risks.