高等学校化学学报2024，Vol.45Issue(7)：37-46,10.DOI:10.7503/cjcu20240103
基于低共熔策略合成碳纳米聚合物用于多种生物小分子的同时电化学检测
Synthesis of Carbon Nanopolymers Based on Deep Eutectic Strategy for Simultaneous Electrochemical Detection of a Variety of Biological Small Molecules
摘要
Abstract
A conductive polymer material poly(3,4-ethylene dioxythiophene)(PEDOT)was synthesized based on a deep eutectic strategy and combined with gold nanoparticles(Au NPs)to construct a novel electrochemical sensing platform to realize the simultaneous determination of a variety of small biological molecules[ascorbic acid(AA),dopamine(DA),uric acid(UA)].The morphology,performance and effective area of glassy carbon electrode modified by PEDOT and Au NPs(PEDOT-Au/GCE)were characterized.The experimental results show that the modified electrode can achieve simultaneous detection of AA,DA and UA with high sensitivity and high stability,proving that the PEDOT-Au NPs complex has good electrochemical catalytic activity.Under optimal experimental conditions,the concentration and peak current value of AA,DA and UA in mixed solution show a good linear relationship in the concentration ranges of 100-1000,50-500 and 22.5-225 μmol/L,respectively,with the separate detection limits of 21,0.38 and 0.016 μmol/L.In addition,the electrochemical sensing platform has a high specificity for AA,DA,and UA in the presence of other active small molecules in serum.This method is applied for the recovery determination of AA,DA and UA in serum samples.关键词
低共熔策略/聚3,4-乙烯二氧噻吩(PEDOT)/电化学传感器/生物小分子Key words
Deep eutectic strategy/Poly(3,4-ethylene dioxythiophene)(PEDOT)/Electrochemical sensor/Small biological molecule分类
化学引用本文复制引用
韦朝鲜,李南盛,庞元昊,张云,金文英,袁亚利..基于低共熔策略合成碳纳米聚合物用于多种生物小分子的同时电化学检测[J].高等学校化学学报,2024,45(7):37-46,10.基金项目
国家自然科学基金(批准号:22364011)资助.Supported by the National Natural Science Foundation of China(No.22364011). （批准号:22364011）
