高等学校化学学报2024，Vol.45Issue(7)：92-100,9.DOI:10.7503/cjcu20240024
利用脂溶性硅基载体连续流动液相合成维洛斯肽
Continuous Flow Liquid-phase Vialox Peptide Synthesis Using Hydrophobic Silyl Tag
摘要
Abstract
A novel hydrophobic silyl tag bis{4-[(tert-butyldiphenylsilyl)oxy]phenyl}methanamine(BPPM)was proposed for rapid liquid-phase peptide synthesis under continuous flow in a microreactor.The designed continuous flow device consists of a coupling unit(micro-channel reactor),a deprotection unit(packed-bed reactor)and a washing unit(micro-channel mixer).In this process,a green solvent(ethyl acetate instead of N,N-dimethylace-tamide)and Cbz-protected amino acids(clean deprotection instead of piperidine Fmoc-deprotection)were used.Vialox peptide with high purity(>95%crude)was synthesized in an environmentally friendly way,with high synthesis efficiency(each amino acid per coupling<5 min).The results are easy to scale up and provide a new strategy for large-scale green and efficient synthesis of peptides.关键词
脂溶性硅基载体/连续流动/液相多肽合成Key words
Hydrophobic silyl tag/Continuous flow/Liquid-phase peptide synthesis分类
化学引用本文复制引用
刘豪,刘冬梅,孙浩田,夏超,苏贤斌..利用脂溶性硅基载体连续流动液相合成维洛斯肽[J].高等学校化学学报,2024,45(7):92-100,9.基金项目
省部共建生态化工协同创新中心人才基金(批准号:1203042904001419)资助.Supported by the Talents Fund of the Provincial and Provincial Cooperative Innovation Center for Ecological Chemical Industry,China(No.1203042904001419). （批准号:1203042904001419）
