肝胆胰外科杂志2024，Vol.36Issue(7)：400-406,411,8.DOI:10.11952/j.issn.1007-1954.2024.07.003
术前身体质量指数对肝门部胆管癌根治性切除术后感染影响的多中心研究
Association between preoperative body mass index and postoperative infection in patients undergoing radical resection for perihilar cholangiocarcinoma:A multicentre study
王婧婧 1车晓宇 1左菁华 1庞书杰 2陈龙飞 3白洁 1殷显玉 1陈志宇 1邱琰1
作者信息
- 1. 陆军军医大学第一附属医院 肝胆外科/全军肝胆外科研究所,重庆 400038
- 2. 海军军医大学附属东方肝胆外科医院 肝胆外科,上海 200438
- 3. 遵义医科大学第三附属医院 普通外科,贵州 遵义 563099
- 折叠
摘要
Abstract
Objective To explore the relationship between preoperative BMI and postoperative infection in patients undergoing radical pCCA resection.Methods This study was a retrospective study.All data were collected from a multicentre database of the First Affiliated Hospital of Army Medical University,Eastern Hepatobiliary Surgery Hospital,and the Third Affiliated Hospital of Zunyi Medical University.Clinical data of patients undergoing radical pCCA resection were included in the database between Jan.2008 and Dec.2022.According to the value of preoperative body mass index(BMI),366 patients were divided into the low BMI group(BMI≤18.4 kg/m2),the normal BMI group(18.4 kg/m2<BMI<25.0 kg/m2)and the high BMI group(BMI≥25.0 kg/m2).Postoperative infection was the outcome of the study,including incision site infection,organ/lacuna infection,and distant infection.The incidence of postoperative infection among the 3 groups was compared.Univariate and multivariate Logistic regression models were used to determine the independent risk factors associated with postoperative infection.Results The incidences of total postoperative infection and incision site infection in the low BMI group and the high BMI group were significantly higher than that in the normal BMI group(total postoperative infection:45.2%,51.8%vs 26.5%,P=0.029 and P<0.001;incision site infection:32.3%,35.7%vs 16.8%,P=0.036 and P=0.001).Multivariable Logistic regression model analysis found that low BMI and high BMI were independently correlated with total postoperative infection(low BMI vs normal BMI:OR=2.380,95%CI 1.103-5.136;high BMI vs normal BMI:OR=3.224,95%CI 1.740-5.972)and incision site infection(low BMI vs normal BMI:OR=2.601,95%CI 1.139-5.941;high BMI vs normal BMI:OR=2.451,95%CI 1.279-4.698).Conclusion pCCA patients with abnormal BMI have a higher risk of postoperative infection after radical resection surgery.For pCCA patients,it is necessary to strengthen perioperative management of abnormal BMI,to reduce the risk of postoperative infection.关键词
术后感染/手术部位感染/身体质量指数/肝门部胆管癌/根治性切除术Key words
postoperative infection/surgical site infection/body mass index/peirhilar cholangiocarcinoma/radical resection分类
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王婧婧,车晓宇,左菁华,庞书杰,陈龙飞,白洁,殷显玉,陈志宇,邱琰..术前身体质量指数对肝门部胆管癌根治性切除术后感染影响的多中心研究[J].肝胆胰外科杂志,2024,36(7):400-406,411,8.
