中医学报2024，Vol.39Issue(7)：1374-1383,10.DOI:10.16368/j.issn.1674-8999.2024.07.228
基于肠道菌群探讨从中医脾胃论治糖尿病肾病
Research Progress on Treatment of Diabetic Kidney Disease from Spleen and Stomach in TCM Based on Gut Microbiota
摘要
Abstract
In TCM,the pathogenesis of diabetic kidney disease(DKD)is the depletion of Yin and fluid with excessive dry Heat.The key lies in the deficiency in root and excess in treetop,to be more specific,it refers to the deficiency of Liver,Spleen and Kidney,as well as induced Qi stagnation,blood stasis,Phlegm,Turbidity and Toxin,Damp-Heat and so on.Gut microbiota can maintain the integrity of the intestinal epithelial barrier,prevent pathogen colonization and regulate immune function.The Phlegm,stagnation,Heat,stasis and Turbidity block in collaterals,caused by Evil factor stagnation transformed into Heat believed in Spleen and Stomach theory of TCM,are similar to the pathological mechanism in modern medicine such as gut microbiota,inflammation,oxidative stress,lipid metabolic disor-ders and hemodynamic abnormalities.From this prospect,probiotics and fecal microbiota transplantation can be used to treat DKD effec-tively with low risk.In addition,Chinese medicine monomer,Chinese patent medicine and Chinese medicine compound can regulate the metabolism of gut microbiota and small molecular substances,playing a beneficial role in the body's metabolism,immunity,inflammatory response,and intestinal function,thus delaying the development of DKD.关键词
糖尿病肾病/肠道菌群/中医脾胃理论/菌群代谢物/中药Key words
diabetic kidney disease/gut microbiota/Spleen and Stomach theory in TCM/microbial metabolites/traditional Chinese med-icine分类
中医学引用本文复制引用
王慧玲,黄国东,陈宇,刘少芳,莫超..基于肠道菌群探讨从中医脾胃论治糖尿病肾病[J].中医学报,2024,39(7):1374-1383,10.基金项目
国家自然科学基金项目(81960913) （81960913）
广西医学高层次骨干人才培养"139"计划项目{桂卫科教发[2020]15号} （）
广西岐黄学者培养项目{桂中医药科教发[2022]10号} （）
广西名中医传承工作室项目{桂中医药科教发[2021]6号} （）
