基于肠道菌群及其代谢物探析骨松益骨方抗绝经后骨质疏松症OACSTPCD
Gusong Yigu Formula for Treating Postmenopausal Osteoporosis Based on Gut Microbiota and Metabolites
绝经后卵巢功能衰竭引起的雌激素缺失是绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的诱发因素,而且雌激素缺乏也会诱发肠道菌群失调,最终促使骨的吸收及破骨细胞的激活.肠道菌群紊乱易引起肠道上皮细胞屏障功能损伤,使有害代谢物可以顺利透过肠道屏障入血,诱发机体T细胞免疫反应,生成大量促破骨细胞生成因子,促使破骨细胞激活及骨的吸收,引发骨质疏松.中药复方具有多组分、多靶点、多层次、见效快等特点,在调节肠道菌群方面优势…查看全部>>
The lack of estrogen caused by postmenopausal ovarian function failure is the inducing factor of postmenopausal osteoporosis(PMOP),which can also induce disorder of gut microbiota to influence the disease.In details,the disorder of gut microbiota can easily cause damage to the barrier function of intestinal epithelial cells,so that harmful metabolites can smoothly pass through into the blood and lead to the body's T-cell immune response to produce many pro-o…查看全部>>
郑旭霞;魏立伟;谢艳;张虹;秦娜
河南省洛阳正骨医院(河南省骨科医院),河南 郑州 450016河南省洛阳正骨医院(河南省骨科医院),河南 郑州 450016河南省洛阳正骨医院(河南省骨科医院),河南 郑州 450016河南省洛阳正骨医院(河南省骨科医院),河南 郑州 450016河南省洛阳正骨医院(河南省骨科医院),河南 郑州 450016
中医学
绝经后骨质疏松症肠道菌群代谢产物骨松益骨方
ostmenopausal osteoporosisgut microbiotametaboliteGusong Yigu Formula
《中医学报》 2024 (7)
1388-1393,6
2021年度河南省中医药科学研究专项课题项目(20-21ZY1063)
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