氧化应激在类风湿关节炎炎症反应中的作用OACSTPCD

Oxidative stress(OS)plays an important role in the inflammatory response of rheumatoid arthritis(RA),which is not only the inducing factor of the disease,but also its important pathological result.The pathogenesis of RA is complicated.Oxidative stress mainly affects the expression of inflammatory response by regulating the activity of proinflammatory cytokines,abnormal proliferation of synovial fibroblasts and fibroblast-like synoviocyte,activation of nitric oxide and prostaglandin E2,excessive growth of synovial blood vessels,pannus formation,lipid peroxidation and other pathological reactions,leading to oxidative damage in the body.At present,the pathophysiological research of RA is mostly based on a single mechanism,and the research on the mechanism of"inflammatory reaction-oxidative stress"is still in the early stage.In the future,it is necessary to further explore the internal correlation between various injury mechanisms and clarify the role of oxidative stress in RA inflammatory response,to provide new ideas for the clinical treatment of RA.