中医学报2024，Vol.39Issue(7)：1454-1461,8.DOI:10.16368/j.issn.1674-8999.2024.07.243
中医药调控Nrf2信号通路防治顺铂所致肝肾损伤研究进展
Research Progress of TCM Preventing and Treating Cisplatin-induced Hepatic and Renal Injury by Regulating Nrf2 Signaling Pathway
摘要
Abstract
The activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway is one of the important protective mechanisms to improve cisplatin-induced liver and kidney toxicity.Traditional Chinese medicine can improve the body's anti-oxidative stress a-bility by regulating Nrf2 signaling pathway and improve cisplatin-induced Liver and Kidney injury.For example,traditional Chinese medicine monomers and Chinese medicine compounds such as Liuwei Dihuang Pill and Shenfushu Granule,which contain flavonoids,phenols and terpenoids as the main active components.However,there are still shortcomings in the research of TCM in preventing and treating Cisplatin-induced Liver and Kidney injury by regulating Nrf2 signaling pathway.For example,Nrf2 signaling pathways often acts in concert with mitogen-activated protein kinase(MAPK),nuclear factor-κB(NF-κB),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)to improve the ability to anti-oxidative stress,inhibit apoptosis and anti-fibrosis effect,while the crossing mechanism between pathways remains to be clarified;In addition,some traditional Chinese medicines have limitations such as poor water solubility and low bioavailability.What's more,the active ingredients of traditional Chinese medicine compound are complex,and the pharmacological effects are not clear yet.Moreover,the depth and breadth of research on acupuncture and moxibustion therapy are not enough.In the future,it is necessary to further standardized the basic experimental design to provide a basis for the treatment of cisplatin-induced Liver and Kidney injury with TCM and give full play to the effect of traditional Chinese medicine in increasing effi-ciency and reducing toxicity.关键词
肝肾损伤/顺铂/Nrf2信号通路/MAPK/NF-κB/PI3K/AktKey words
liver and kidney injury/cisplatin/Nrf2 signaling pathway/MAPK/NF-κB/PI3K/Akt分类
医药卫生引用本文复制引用
王永欣,刘亚敏,滕迎春,谷文琪,韩乐,王建明,王晴晴,吴昊,刘文娇..中医药调控Nrf2信号通路防治顺铂所致肝肾损伤研究进展[J].中医学报,2024,39(7):1454-1461,8.基金项目
国家自然科学基金委员会青年基金项目(81804196) （81804196）
河南省省级科技研发计划联合基金项目(优势学科培育类)(222301420077) （优势学科培育类）
河南省卫生健康委员会中医药科学研究专向课题项目(2022ZY2041) （2022ZY2041）
