中医学报2024，Vol.39Issue(7)：1470-1475,6.DOI:10.16368/j.issn.1674-8999.2024.07.245
中医药干预OPG/RANKL/RANK信号通路防治骨质疏松症研究进展
Research Progress of TCM in Treating Osteoporosis by Regulating OPG/RANKL/RANK Signaling Pathway
摘要
Abstract
OPG/RANKL/RANK signaling pathway is one of the major discoveries in bone biology in recent years.It plays an important role in bone homeostasis and bone remodeling and has become a target for the treatment of osteoporosis.This pathway is important in the regulation of bone metabolism and is closely related to osteoclast function.From this prospect,traditional Chinese medicine monomer and its extracts,traditional Chinese medicine compound formula,acupuncture,moxibustion,acupoint catgut embedding and other therapies can inhibit the differentiation and maturation of osteoclasts and promote bone formation by regulating the OPG/RANKL/RANK pathway,thus influencing the prevention and treatment of osteoporosis.Although the current research on the mechanism of TCM in treating osteoporosis has made some achievements,it mainly focuses on the regulation of osteoblasts and osteoclasts.Therefore,further studies on cell senes-cence,bone immunity,intestinal flora disorder,energy metabolism of osteoblasts and iron homeostasis can be carried out in the future.关键词
骨质疏松症/OPG/RANKL/RANK信号通路/成骨细胞/破骨细胞Key words
osteoporosis/OPG/RANKL/RANK signaling pathway/osteoblasts/osteoclasts分类
中医学引用本文复制引用
董佩,袁普卫,康武林,白元帅,王振凯,高亚丽..中医药干预OPG/RANKL/RANK信号通路防治骨质疏松症研究进展[J].中医学报,2024,39(7):1470-1475,6.基金项目
陕西省中医药管理局项目(2022-SLRH-LJ-001) （2022-SLRH-LJ-001）
陕西中医药大学学科建设创新团队项目(2019YL-02) （2019YL-02）
长安医学关中李氏骨伤学术流派传承工作室建设项目{陕中医药发[2018]40号} （）
陕西省骨退行性疾病中西医结合防治重点研究室建设项目{陕中医药发[2018]32号} （）
