中医学报2024，Vol.39Issue(7)：1484-1491,8.DOI:10.16368/j.issn.1674-8999.2024.07.247
中药协同抗生素抑制金黄色葡萄球菌生物膜形成研究进展
Research Progress of TCM Combined with Antibiotics in Inhibiting Staphylococcus Aureus Biofilm Formation
摘要
Abstract
The production of bacterial biofilm is the main factor of drug resistance of Staphylococcus aureus,which greatly enhances the immune defense to the body and the resistance to antibiotics.Traditional Chinese medicine and its compounds have the characteristics of multi-path and multi-target,which can prevent Staphylococcus aureus from forming complete biofilm by interfering with its quorum-sensing system,global regulatory factors,and extracellular matrix to regulate the proliferation,aggregation and spread of Staphylococcus aureus.At the same time,TCM has a good antibacterial effect,which can be used in combination with antibiotics to deal with infection,avoid antibiotic abuse and bacterial resistance,effectively reduce the generation of drug-resistant strains,and promote wound healing.However,there are few clinical studies on TCM combined with antibiotics in inhibiting staphylococcus aureus biofilm formation.It is ur-gent to strengthen the pharmacological research of TCM against Staphylococcus aureus cell membrane,especially the TCM effect on sig-nal transduction and regulation mechanism in cells.In addition,the clinical trials of the combination of nanomaterials and TCM mole-cules should be further strengthened to improve the efficiency of drug use,reduce the adverse reactions,and provide new ideas for sol-ving refractory Staphylococcus aureus infection induced by bacterial biofilm.关键词
中药/抗生素/金黄色葡萄球菌/细菌生物膜Key words
traditional Chinese medicine(TCM)/antibiotic/staphylococcus aureus/bacterial biofilm分类
中医学引用本文复制引用
王瑜豪,于进洋,王圣睿,王啸,史小涛,袁彦浩,谭红略..中药协同抗生素抑制金黄色葡萄球菌生物膜形成研究进展[J].中医学报,2024,39(7):1484-1491,8.基金项目
国家自然科学基金面上项目(U1804189) （U1804189）
