转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展OACSTPCD
Progress on the role of transketolase in occurrence and treatment of diabetes and its complications
转酮醇酶(TKT)是催化磷酸戊糖途径(PPP)非氧化阶段基团转移反应的重要酶,参与机体各类能源物质,如葡萄糖、核糖、核苷酸以及脂质的代谢.TKT可以通过抑制高糖环境下蛋白质和脂质非酶糖基化(NEG)产生的晚期糖基化终末产物(AGEs),减少氧化应激、炎性反应、动脉粥样硬化、内皮功能障碍以及Tau蛋白磷酸化等,进而改善血糖、糖耐量和β细胞功能,达到预防和治疗糖尿病及其并发症的作用.
Transketolase(TKT)is an important enzyme that catalyzes the non-oxidative phase group transfer reac-tion of pentose phosphate pathway(PPP),and is involved in the metabolism of various energy substances in the body,such as glucose,ribose,nucleotides and lipids.TKT can reduce oxidative stress,inflammation,atheroscle-rosis,endothelial dysfunction and Tau protein phosphorylation by inhibiting advanced glycated end-produces(AGEs)produced by non-enzymatic glycosylation(NEG)of proteins and lipids in a high-glucose environment im-proving blood glucose,glucose tolerance and β cell function so to prevent and treat diabetes and its complications.This article reviews research progress on the mechanism of TKT in the treatment of diabetes mellitus and its compli-cations.
王泽颖;刘治;邰玉;杨忠彬;苏燕
包头医学院 生物化学与分子生物学教研室,内蒙古 包头 014010
基础医学
转酮醇酶糖尿病代谢磷酸戊糖途径
transketolasediabetesmetabolismpentose phosphate pathway
《基础医学与临床》 2024 (007)
1023-1028 / 6
国家自然科学基金(81860029);内蒙古自然科学基金(2020MS08008);草原英才滚动计划(2021);2021 年卫生健康科技计划(202201394)
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