基础医学与临床2024，Vol.44Issue(7)：1023-1028,6.DOI:10.16352/j.issn.1001-6325.2024.07.1023
转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展
Progress on the role of transketolase in occurrence and treatment of diabetes and its complications
摘要
Abstract
Transketolase(TKT)is an important enzyme that catalyzes the non-oxidative phase group transfer reac-tion of pentose phosphate pathway(PPP),and is involved in the metabolism of various energy substances in the body,such as glucose,ribose,nucleotides and lipids.TKT can reduce oxidative stress,inflammation,atheroscle-rosis,endothelial dysfunction and Tau protein phosphorylation by inhibiting advanced glycated end-produces(AGEs)produced by non-enzymatic glycosylation(NEG)of proteins and lipids in a high-glucose environment im-proving blood glucose,glucose tolerance and β cell function so to prevent and treat diabetes and its complications.This article reviews research progress on the mechanism of TKT in the treatment of diabetes mellitus and its compli-cations.关键词
转酮醇酶/糖尿病/代谢/磷酸戊糖途径Key words
transketolase/diabetes/metabolism/pentose phosphate pathway分类
医药卫生引用本文复制引用
王泽颖,刘治,邰玉,杨忠彬,苏燕..转酮醇酶在糖尿病及其并发症发生和治疗中作用的研究进展[J].基础医学与临床,2024,44(7):1023-1028,6.基金项目
国家自然科学基金(81860029) （81860029）
内蒙古自然科学基金(2020MS08008) （2020MS08008）
草原英才滚动计划(2021) （2021）
2021 年卫生健康科技计划(202201394) （202201394）
