解剖学杂志2024，Vol.47Issue(2)：95-100,6.DOI:10.3969/j.issn.1001-1633.2024.02.001
果糖在肝胰岛素抵抗发生机制中的作用
The role of fructose in the pathogenesis of hepatic insulin resistance
摘要
Abstract
With economic development,diabetes has become one of the most common chronic diseases globally,and liver insulin resistance is one of the key factors for the occurrence and development of type 2 diabetes mellitus.This paper reviews the studies on the direct effects of fructose on insulin pathway and the indirect blocking of insulin pathway through increasing de novo synthesis of liver lipids,weakening fatty acid oxidation in hepatocytes,activating oxidative stress in hepatocytes,and enhancing hepatic inflammatory responses.It provides a new perspective for the diagnosis and treatment of obesity,type 2 diabetes and other diseases closely related to hepatic insulin resistance.关键词
肝/果糖/胰岛素抵抗/糖尿病Key words
liver/fructose/insulin resistance/diabete分类
医药卫生引用本文复制引用
杨佳叶,卢奕成,张晓明..果糖在肝胰岛素抵抗发生机制中的作用[J].解剖学杂志,2024,47(2):95-100,6.基金项目
国家级大学生创新创业训练计划项目(202310335067) （202310335067）
浙江省大学生创新创业训练计划项目(2022R401072) （2022R401072）
