检验医学与临床2024，Vol.21Issue(13)：1831-1835,5.DOI:10.3969/j.issn.1672-9455.2024.13.002
阿托西班联合地塞米松对胎膜早破孕妇的治疗效果及对8-iso-PG、Cor、NE水平的影响
The therapeutic effect of atosiban combined with dexamethasone on pregnant women with premature rupture of membranes and its influence on 8-iso-PG,Cor and NE levels
摘要
Abstract
Objective To investigate the therapeutic effect of atosiban combined with dexamethasone on pregnant women with premature rupture of membranes and its influence on oxidative stress response indica-tors[8-iso-prostaglandin(8-iso-PG),cortisol(Cor),norepinephrine(NE)]levels.Methods A total of 110 patients with premature rupture of membranes admitted to the Second Hospital of Baoding in Hebei Province from October 2019 to October 2021 were selected as the research objects.According to the random number ta-ble method,they were divided into observation group and control group,with 55 cases in each group.Both groups were given conventional treatment of premature rupture of membranes,the control group was treated with dexamethasone on the basis of conventional treatment,and the observation group was treated with atosi-ban on the basis of the control group.The clinical efficacy,symptom improvement indicators,adverse maternal and infant outcomes,oxidative stress indicators and treatment safety were compared between the two groups after treatment.Results After treatment,the total effective rate of the observation group was 92.73％(51/55),which was higher than 76.36％(42/55)of the control group,and the difference was statistically signifi-cant(P＜0.05).After treatment,the drug effective time and uterine contraction inhibition time of the obser-vation group were lower than those of the control group(P＜0.05),and the prolonged duration of pregnancy pomfret control group(P＜0.05).After treatment,the incidence of cesarean section,postpartum hemorrhage,amniotic cavity infection,fetal distress and neonatal asphyxia in the observation group were lower than those in the control group(P＜0.05).After treatment,the levels of 8-iso-PG,Cor and NE in the two groups were lower than those before treatment(P＜0.05).and the levels of 8-iso-PG,Cor and NE in the observation group were lower than those in the control group(P＜0.05).During the treatment,the incidence of adverse reac-tions in the observation group and the control group was 14.55％(8/55)and 9.09％(5/55)respectively,and there was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Atosiban combined with dexamethasone has a good therapeutic effect on patients with premature rupture of membranes,which can inhibit the uterine contraction of patients,prolong the preg-nancy time,improve the maternal and infant outcomes of pregnant women,and inhibit the levels of 8-iso-PG,Cor and NE,and the treatment safety is good.关键词
胎膜早破/地塞米松/阿托西班/临床疗效/母婴结局/血清标记蛋白Key words
premature rupture of membrane/dexamethasone/atosiban/clinical efficacy/maternal and infant outcome/serum labeled protein分类
医药卫生引用本文复制引用
孙雪,杨春艳,马艳丽,马春星,李静..阿托西班联合地塞米松对胎膜早破孕妇的治疗效果及对8-iso-PG、Cor、NE水平的影响[J].检验医学与临床,2024,21(13):1831-1835,5.基金项目
河北省医学科学研究课题计划(20200170). （20200170）
