检验医学与临床2024，Vol.21Issue(13)：1851-1854,4.DOI:10.3969/j.issn.1672-9455.2024.13.006
血清cMyBP-C对急性心肌梗死早期的诊断价值
Serum cMyBP-C value to the diagnosis of early of acute myocardial infarction
摘要
Abstract
Objective To investigate the value of serum cardiac myosin binding protein C(cMyBP-C)in the early diagnosis of acute myocardial infarction(AMI).Methods A total of 90 AMI patients admitted to the hospital from January 2022 to January 2023 were selected as the observation group.In addition,90 non-AMI patients admitted to the hospital during the same period were selected as the control group.The levels of cMyBP-C,serum creatine kinase isoenzyme(CK-MB),myoglobin(Myo)and high-sensitivity cardiac troponin T(hscTnT)were detected and compared between the two groups,and the correlation between serum cMyBP-C level and CK-MB,Myo and hscTnT levels in AMI patients was analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the value of serum cMyBP-C,CK-MB,Myo,hscTnT alone and cMyBP-C combined with hscTnT in the early diagnosis of AMI.Spearman correlation analysis was used to analyze the correlation between serum cMyBP-C level and CK-MB,Myo,hscTnT levels in AMI patients.Results The levels of serum cMyBP-C,CK-MB,Myo and hscTnT in the observation group were higher than those in the control group(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of cMyBP-C,CK-MB,Myo,hscTnT alone and cMyBP-C combined with hscTnT in the diagnosis of AMI was 0.96,0.76,0.81,0.95,0.98 respectively.The AUC of serum cMyBP-C,CK-MB,Myo,and hscTnT alone was lower than that of the combined detection of cMyBP-C and hscTnT(P＜0.05).Spearman correlation analysis showed that the level of cMyBP-C was positively correlated with the levels of CK-MB and Myo in AMI patients(r=0.381,0.409,P＜0.05).There was no correlation between cMyBP-C level and hscTnT level(r=0.062,P＞0.05).Conclusion Serum cMyBP-C,CK-MB,Myo and hscTnT can be used as early diagnostic indicators for AMI,and the combined detection of cMyBP-C and hscTnT in the diagnosis of AMI is better than the single detection of the above four indicators.cMyBP-C has an important value in the early diagnosis of AMI,and it can be used as one of the important indicators for the clinical diagnosis of early AMI.关键词
心肌梗死/心肌肌球蛋白结合蛋白C/早期诊断/超敏心肌肌钙蛋白T/肌红蛋白Key words
myocardial infarction/cardiac myosin binding protein C/early diagnosis/high-sensitivity cardiac troponin T/myoglobin分类
医药卫生引用本文复制引用
李云豪,李菁,彭欢子,许莹芊,王金全,彭嘉琪,谢小兵..血清cMyBP-C对急性心肌梗死早期的诊断价值[J].检验医学与临床,2024,21(13):1851-1854,4.基金项目
湖南省卫生健康委科研课题(202211003853) （202211003853）
湖南省科技厅重点领域研发计划-重点研发(2022GK2057) （2022GK2057）
湖南中医药大学学科建设"揭榜挂帅"项目(22JBZ037). （22JBZ037）
