检验医学与临床2024，Vol.21Issue(13)：1880-1884,5.DOI:10.3969/j.issn.1672-9455.2024.13.012
血清Trx1、VILIP-1对急性分水岭脑梗死患者预后不良的预测价值
The predictive value of serum Trx1 and VILIP-1 for poor prognosis in patients with acute watershed cerebral infarction
摘要
Abstract
Objective To explore the predictive value of serum thioredoxin 1(Trx1)and cone-like protein-1(VILIP-1)for poor prognosis in patients with acute watershed cerebral infarction(ACW1).Methods A to-tal of 126 ACWI patients who were treated in Handan First Hospital of Hebei Province from December 2019 to December 2022 were selected as the research objects.The clinical data of all patients were collected.The levels of triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and total cholesterol(TC)were detected in all patients.According to the modified Rankin scale score at 90 days of follow-up,the patients were divided into good prognosis group and poor prognosis group.The serum levels of Trx1 and VILIP-1 were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the risk factors of influencing prognosis in ACWI patients.The receiv-er operating characteristic(ROC)curve was drawn to analyze the predictive value of Trx1,VILIP-1 alone and combination of the two indexes for poor prognosis of ACWI patients.Results The 90 days follow-up results showed that there were 85 patients in the good prognosis group and 41 patients in the poor prognosis group.The proportion of patients with massive cerebral infarction,National Institute of Health Stroke Scale(NIH-SS)score,serum TG,TC,and LDL-C levels in the poor prognosis group were significantly higher than those in the good prognosis group,and the serum HDL-C level was significantly lower than that in the good progno-sis group(P＜0.05).The serum Trx1 level of the poor prognosis group was significantly lower than that of the good prognosis group,and the serum VILIP-1 level was significantly higher than that of the good progno-sis group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analy-sis showed that increased NIHSS score and VILIP-1 level were risk factors for poor prognosis in patients with ACWI(P＜0.05),and increased Trx1 level was a protective factor for poor prognosis in patients with ACWI(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of Trx1 and VILIP-1 for predic-ting the poor prognosis of ACWI patients was 0.782 and 0.814 respectively,which was lower than 0.905 of combined detection of the two indicators(Z=2.487,2.350,P＜0.05).Conclusion Decreased serum Trx1 level and increased VILIP-1 level were associated with poor prognosis of ACWI patients.Both of them can as-sist in judging the prognosis of patients,and the combined detection of the two has a higher predictive value for poor prognosis of ACWI patients.关键词
急性分水岭脑梗死/硫氧还蛋白1/视锥蛋白样蛋白-1/总胆固醇/预测价值Key words
acute watershed cerebral infarction/thioredoxin 1/opsin like protein-1/total cholester-ol/predictive value分类
临床医学引用本文复制引用
韩韶,侯艳苹,马岩朋,周涛,祝春燕..血清Trx1、VILIP-1对急性分水岭脑梗死患者预后不良的预测价值[J].检验医学与临床,2024,21(13):1880-1884,5.基金项目
河北省卫健委资助项目(20200185). （20200185）
