检验医学与临床2024，Vol.21Issue(13)：1972-1976,5.DOI:10.3969/j.issn.1672-9455.2024.13.030
外膜囊泡在幽门螺杆菌定植与致病中的作用及其应用价值
Role of outer membrane vesicles in Helicobacter pylori colonization and pathogenesis and its application value
欧国俞 1谭东 1邹霞 1杨林 1万秋斌 1朱银川1
作者信息
- 1. 重庆市丰都县人民医院医学检验科,重庆 408200
- 折叠
摘要
Abstract
Helicobacter pylori(Hp),as a class Ⅰ carcinogen,has infected more than half of the world's population and is one of the causes of chronic gastritis,gastroduodenal ulcer,gastric cancer,gastric muco-asso-ciated lymphoid tissue and lymphoma.At present,Hp can interact with host gastric epithelial cells through cell proteins,secretory enzymes and related toxin factors to increase the risk of precancerous lesions and canc-er.More and more studies have shown that the outer membrane vesicles(OMVs)formed by spontaneous shedding of Hp contain many enzymes and toxins,but also have obvious small-molecule advantages,and play an important role in the survival and chronic infection of Hp.At the same time,OMVs also show good poten-tial application value in the development of Hp vaccine,small molecule transport vector and biomarker appli-cation.This paper summarizes the role of Hp OMVs in Hp colonization and pathogenicity,and look forward to its role in anti-tumor and drug-resistant gene transmission,in order to provide new ideas and directions for drug development and disease diagnosis and treatment.关键词
幽门螺杆菌/外膜囊泡/定植/致病因素/致癌物质Key words
Helicobacter pylori/outer membrane vesicle/colonization/pathogenic factor/carcinogen分类
医药卫生引用本文复制引用
欧国俞,谭东,邹霞,杨林,万秋斌,朱银川..外膜囊泡在幽门螺杆菌定植与致病中的作用及其应用价值[J].检验医学与临床,2024,21(13):1972-1976,5.
