昆明医科大学学报2024，Vol.45Issue(7)：42-48,7.DOI:10.12259/j.issn.2095-610X.S20240706
阑尾黏液性肿瘤临床病理及分子病理特征分析
Analysis of the Clinicopathological and Molecular Features of Appendiceal Mucinous Neoplasms
摘要
Abstract
Objective To investigate the clinicopathological and molecular features of appendiceal mucinous neoplasms(AMNs),compare the differences bewteen the LAMN and HAMN.Methods 32 cases of AMNs were collected between January 2015 and September 2021.They were hospitalized in the Affiliated Hospital of Southwest Medical University.10 samples of them were selected for Next Generation Sequencing(NGS)analysis of 425 genes.Results The majority of AMNs were female(68.8%).Most patients had positive tumor markers.The proportion of distant metastasis,recurrence and death in HAMN patients were higher than those in LAMN patients.KRAS,GNAS and BRAF gene mutations were common in AMNs patients.The SNP of MTHFR and NQO1 were common in AMNs patients.The TMB of LAMN and HAMN patients were both lower,and there was no statistical significance between them(P>0.05).Conclusion AMNs have special clinical pathological and molecular pathological changes,but there is no significant difference between HAMN and LAMN.关键词
阑尾黏液性肿瘤/临床病理特征/分子病理特征/高通量测序Key words
Appendiceal mucinous neoplasms/Clinicopathological features/Molecular features/Next generation sequencing分类
医药卫生引用本文复制引用
王学丹,刘一帆,杨子寒,张丹丹,段怡,杨志惠..阑尾黏液性肿瘤临床病理及分子病理特征分析[J].昆明医科大学学报,2024,45(7):42-48,7.基金项目
四川省科技厅科技计划基金资助项目(No.2022YFS0636) （No.2022YFS0636）
