南京医科大学学报（自然科学版）2024，Vol.44Issue(7)：927-933,7.DOI:10.7655/NYDXBNSN231145
新诊断2型糖尿病患者亚临床颈动脉粥样硬化的影响因素及综合治疗后的转归情况
Factors influencing subclinical carotid atherosclerosis in patients with newly diagnosed type 2 diabetes mellitus and regression after comprehensive treatments
摘要
Abstract
Objective:To investigate the influencing factors associated with subclinical carotid atherosclerosis(SCAS)in patients with newly diagnosed type 2 diabetes mellitus(T2DM)and regression after comprehensive treatments.Methods:Data were collected from 402 patients with newly diagnosed T2DM,grouped according to the presence or absence of SCAS,and the differences in the indicators between the two groups were compared.Using binary logistic regression to analyze factors influencing newly diagnosed T2DM combined with SCAS.Cut-off values for risk factors were analyzed using reciever operating characteristic(ROC)curves.Seventy-two of these patients were followed up to compare the target accomplishment rates of metabolic index and SCAS detection rate before and after the comprehensive treatment.Results:The SCAS detection rate among 402 newly diagnosed T2DM hospitalized patients was 57.0％(229/402).The differences in diabetic peripheral neuropathy(DPN),diabetic retinopathy(DR),estimated glomerular filtration rate(eGFR),triglycerides(TG),body mass index(BMI),and heart rate were statistically significant(P＜0.05)when the SCAS group was compared with the non-SCAS group.Binary logistic regression analysis showed that the independent influences of newly diagnosed T2DM combined with SCAS included DPN,DR,eGFR,and BMI(P＜0.05).ROC curve analysis showed an eGFR cut-off value of 103.50 mL/(min 1.73 m2)and a BMI cut-off value of 27.32 kg/m2.Compared with baseline,patients'carotid intima-media thickness(CIMT),SCAS detection rate and metabolic indexes were significantly improved after one year of intervention,and the difference between the two groups was statistically significant(P＜0.05).Conclusion:The SCAS detection rate in hospitalized patients with newly diagnosed T2DM is high.DPN and DR are positively associated with the risk of newly diagnosed T2DM combined with SCAS.Elevated BMI and decreased eGFR are independent risk factors for newly diagnosed T2DM combined with SCAS.Combination therapy improves metabolic indexes,relieves CIMT thickening,and reduces SCAS detection rate in patients with newly diagnosed T2DM,but carotid artery plaque is not significantly improved.关键词
新诊断2型糖尿病/慢性微血管并发症/亚临床颈动脉粥样硬化Key words
newly diagnosed type 2 diabetes mellitus/chronic microvascular complications/subclinical carotid atherosclerosis分类
医药卫生引用本文复制引用
王祎洁,徐汉文,张文琼,周洁茹,金晶,武晓泓..新诊断2型糖尿病患者亚临床颈动脉粥样硬化的影响因素及综合治疗后的转归情况[J].南京医科大学学报（自然科学版）,2024,44(7):927-933,7.基金项目
浙江省自然科学基金联合基金(LHDMZ23H070001) （LHDMZ23H070001）
浙江省"高层次人才特殊支持计划"科技创新领军人才项目(2021R52022) （2021R52022）
浙江省卫生创新人才项目(2021-CXRC07-01) （2021-CXRC07-01）
