摘要
Abstract
Objective:Hypersensitive C-reactive protein(hs-CRP),Fibrinogen(Fg),Alkaline phosphatase(ALP)and White blood cell count(WBC)in the diagnosis of infection were analyzed after bone injury surgery.Methods:48 patients with infection after bone injury surgery admitted to our hospital from July 2021 to July 2022 were selected as the observation group,and 49 patients who underwent bone injury surgery without infection during the same period were selected as the control group.The serum levels of hs-CRP,Fg,ALP and WBC were compared between the two groups.The levels of hs-CRP,Fg,ALP and WBC in the observation group before and after infection were compared,and the diagnostic value of serum factors was calculated.Results:Infection and time had an interaction effect on the levels of hs-CRP,Fg,ALP and WBC,and the difference was statistically significant(P<0.05).After the first reexamination,the levels of hs-CRP,Fg,ALP and WBC in the observation group were lower than those before treatment,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the Area under curve(AUC)of hs-CRP,Fg,ALP and WBC in the diagnosis of infection in patients with bone injury after surgery was 0.964,0.929,0.913 and 0.798,respectively.Among them,the AUC of hs-CRP was the largest(0.964),the best cut-off value was 3.81,the sensitivity was 87.50%,and the specificity was 93.70%.The ROC results showed that the specificity of WBC and Fg was higher 97.90%.Therefore,the study suggests that the combined detection of hs-CRP,Fg,ALP and WBC is better.Conclusion:For patients with infection after bone injury surgery,the combined detection of hs-CRP,Fg,ALP and WBC has higher diagnostic value,and has good clinical application value for the follow-up observation of the curative effect of patients,which is worthy of promotion.关键词
感染/超敏C反应蛋白/纤维蛋白原/碱性磷酸酶/诊断价值Key words
Infection/High-sensitivity C-reactive protein/Fibrinogen/Alkaline phosphatase/Diagnostic value分类
医药卫生
