抗骨质疏松联合方案对PVP患者骨量的影响OA

Objective:To observe the changes of bone indexes and study the effect of anti-osteoporosis therapy after vertebral augmentation(PVP)for vertebral fracture caused by severe osteoporosis.Methods:36 patients with osteoporotic vertebral fractures(OVCF)were enrolled in this study and treated with PVP.The patients were divided into the treatment group(n=20)and the control group(n=16)according to whether they received CVPC treatment or not.The bone mineral density(BMD)and bone turnover factor(BTMs)levels of the two groups at specified time points were studied,and the efficacy was evaluated combined with visual analogue scale(VAS)score.Results:After 3 months of treatment,the T value of bone mineral density in the two groups was higher than that immediately after treatment,and the treatment group was higher than the control group,but the difference was not statistically significant(P＞0.05).At 6 and 12 months after treatment,the T value of bone mineral density in the treatment group was higher than that immediately after treatment,and the T value in the treatment group was higher than that in the control group,the difference was statistically significant(P＜0.05).The T value of bone mineral density in the control group was higher than that immediately after treatment,but the difference was not statistically significant(P＞0.05).At 3 months after treatment,the levels of procollagen type I amino-terminal propeptide(PINP)and cross-linked carboxy-terminal telopeptide of type I collagen(CTX)in the two groups were higher than those immediately after treatment,and those in the treatment group were higher than those in the control group,but the differences were not statistically significant(P＞0.05).At 6 and 12 months after treatment,the levels of PINP and CTX in the treatment group were higher than those immediately after treatment,and those in the treatment group were higher than those in the control group,the differences were statistically significant(P＜0.05).The levels of PINP and CTX in the control group were higher than those immediately after treatment,but the differences were not statistically significant(P＞0.05).The incidence of re-fracture in the treatment group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in VAS scores between the two groups before operation,immediately after treatment,3 months and 6 months after treatment(P＞0.05).At 12 months after treatment,the VAS score of the treatment group was lower than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion:CVPC regimen after PVP for osteoporotic vertebral fractures can improve bone mineral density,optimize bone turnover level,relieve symptoms,and reduce the incidence of re-fracture.