摘要
Abstract
Objective:To explore the effect of sulfasalazine combined with methotrexate in patients with coercive spondylitis.Methods:86 patients with ankylosing spondylitis admitted to our hospital from February 2020 to February 2023 were selected as the research objects.The patients were divided into a study group and a control group by computer sampling method,with 43 cases in each group.Patients in both groups were treated with methotrexate,and patients in the study group were treated with salazopyridine on the basis of the above,and the therapeutic effect of the two groups was compared.Results:Before treatment,there were no significant differences in serum osteoprotegerin,receptor activator of nuclear factor-κb ligand,25-(OH)D3,vitamin D receptor,and bone-specific alkaline phosphatase levels between the two groups(P>0.05).After treatment,the levels of serum osteoprotegerin and receptor activator of nuclear factor-κb ligand in the two groups were lower than those before treatment,and the levels of 25-(OH)D3,vitamin D receptor and bone specific alkaline phosphatase were higher than those before treatment,and the levels of serum osteoprotegerin and receptor activator of nuclear factor-κb ligand in the study group were lower than those in the control group.The levels of 25-(OH)D3,vitamin D receptor and bone specific alkaline phosphatase in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The effective rate of the study group was 97.67%,which was higher than 83.72%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of MMP-9,hs-CRP,TNF-α and IL-6 between the two groups(P>0.05).After treatment,the levels of MMP-9 in the two groups were higher than those before treatment,and the levels of hs-CRP,TNF-α and IL-6 were lower than those before treatment,and the level of MMP-9 in the study group was higher than that in the control group,and the levels of hs-CRP,TNF-α and IL-6 were lower than those in the control group and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 2.32%,which was lower than 18.60%in the control group,and the difference was statistically significant(P<0.05).Conclusion:In the treatment of patients with ankylosing spondylitis,the application of methotrexate and sulfasalazine treatment is very effective for patients.关键词
强直性脊柱炎/柳氮磺吡啶/甲氨蝶呤/骨特异性碱性磷酸酶Key words
Ankylosing spondylitis/Sulfasalazine/Methotrexate/Bone-specific alkaline phosphatase分类
医药卫生
